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Case Reports
. 2022 Jun 17;15(2):624-629.
doi: 10.1159/000523897. eCollection 2022 May-Aug.

Disseminated Intravascular Coagulopathy in Cranial Surgery: Case Report and Review of the Literature

Christina Wolfert  1 , Ehab Shiban  1 , Björn Sommer  1
Affiliations
Case Reports

Disseminated Intravascular Coagulopathy in Cranial Surgery: Case Report and Review of the Literature

Christina Wolfert et al. Case Rep Oncol. .

Abstract

We present a rare case with multifocal osseous metastases of prostate cancer and disseminated intravascular coagulopathy (DIC). The patient received systemic tumor therapy, including antiandrogen agents as well as cerebral radiation. Due to rapid clinical deterioration, indication for surgery of the space-occupying calvarial metastasis was made as a salvage therapy procedure. Depleted clotting factors were substituted, and patient underwent tumor embolization prior to surgery. Although his neurological status improved postoperatively, the patient died suffering from multiple supra- and infratentorial infarctions. Our case report elucidates the laboratory results and difficulties of DIC in this case as well as possible treatment strategies.

Keywords: Calvarial metastasis; Disseminated intravascular coagulopathy; Prostate cancer; Stroke; Surgery of metastasis.

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Conflict of interest statement

The authors have no relevant financial or nonfinancial interests to disclose.

Figures

Fig. 1
Fig. 1
Extensive osteoblastic calvarial metastasis.
See this image and copyright information in PMC

References

    1. Agrawal K, Agrawal N, Miles L. Disseminated intravascular coagulation as an initial manifestation of metastatic prostate cancer emergently treated with docetaxel-based chemotherapy. Case Rep Oncol Med. 2019 Apr;2019:6092156. - PMC - PubMed
    1. Costello RA, Nehring SM. StatPearls [Internet] Treasure Island, FL: StatPearls Publishing; 2022. Disseminated intravascular coagulation. [cited 2022 Jan 31]. Availiable from: http://www.ncbi.nlm.nih.gov/books/NBK441834/ - PubMed
    1. Kotecha R, Angelov L, Barnett GH, Reddy CA, Suh JH, Murphy ES, et al. Calvarial and skull base metastases: expanding the clinical utility of gamma knife surgery: clinical article. J Neurosurg. 2014 Dec;121 Suppl:91–101. - PubMed
    1. Toh CH, Alhamdi Y, Abrams ST. Current pathological and laboratory considerations in the diagnosis of disseminated intravascular coagulation. Ann Lab Med. 2016;36((6)):505–12. - PMC - PubMed
    1. Taylor FB, Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH) Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86((5)):1327–30. - PubMed

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