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. 2022 Jun 23;12(2):107-114.
doi: 10.1159/000521114. eCollection 2022 May-Aug.

Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia

Maria Lage Barca  1   2 , Dag Alnæs  3   4 , Knut Engedal  1   2 , Karin Persson  1   2 , Rannveig Sakshaug Eldholm  5 , Nikias Siafarikas  6 , Ina Selseth Almdahl  7   8 , Maria Stylianou-Korsnes  7   9 , Ingvild Saltvedt  5   10 , Geir Selbæk  1   2   8 , Lars T Westlye  3   9   11
Affiliations

Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia

Maria Lage Barca et al. Dement Geriatr Cogn Dis Extra. .

Abstract

Introduction: Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI).

Methods: A sample of 492 patients from Norwegian memory clinics (n = 363) and Old Age Psychiatry services (n = 129) was studied. The assessment included the Cornell Scale for Depression in Dementia (CSDD), Instrumental Activities of Daily Living Scale, Mini Mental State Examination, and MRI of the brain, processed with FreeSurfer to derive ROI measures of cortical thickness, volume, and area using the Desikan-Killiany parcellation, as well as subcortical volumes. Dementia was diagnosed according to ICD-10 research criteria. Correlates of brain morphometry using multiple linear regression were examined.

Results: Higher scores on the CSDD were associated with larger cortical volume (β = 0.125; p value = 0.003) and area of the left isthmus of the cingulate gyrus (β = 0.151; p value = <0.001) across all patients. Inclusion of an interaction term (dementia × CSDD) revealed a smaller area in the left temporal pole (β = -0.345; p value = 0.001) and right-transverse temporal cortex (β = -0.321; p value = 0.001) in patients with dementia and depressive symptoms.

Discussion/conclusion: We confirm the previous findings of structural brain changes in temporal regions among patients with dementia and concomitant depressive symptoms. This may contribute to a better understanding of the mechanisms underlying depression in dementia. To the best of our knowledge, this is the largest study conducted on this topic to date.

Keywords: Dementia; Depression; MRI.

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Conflict of interest statement

K.P. performed work in collaboration with Roche BN29553 in 2018 outside of the submitted work. I.S.A. participated in an Advisory Board, Biogen (2020), and at the drug trial by Boehringer-Ingelheim 1346.0023 (2018).

Figures

Fig. 1
Fig. 1
Interaction between dementia and depressive symptoms in regard to the area in the left temporal pole.
Fig. 2
Fig. 2
Interaction between dementia and depressive symptoms in regard to the area in the right-transverse temporal cortex.
See this image and copyright information in PMC

References

    1. Lyketsos CG, Olin J. Depression in Alzheimer's disease: overview and treatment. Biol Psychiatry. 2002;52((3)):243–52. - PubMed
    1. Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, et al. Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry. 2010;18((2)):98–116. - PubMed
    1. Knapskog AB, Barca ML, Engedal K. Prevalence of depression among memory clinic patients as measured by the Cornell Scale of Depression in Dementia. Aging Ment Health. 2014;18((5)):579–87. - PubMed
    1. Barca ML, Engedal K, Laks J, Selbæk G. Quality of life among elderly patients with dementia in institutions. Dement Geriatr Cogn Disord. 2011;31((6)):435–42. - PubMed
    1. Ryden MB, Pearson V, Kaas MJ, Hanscom J, Lee H, Krichbaum K, et al. Nursing interventions for depression in newly admitted nursing home residents. J Gerontol Nurs. 1999;25((3)):20–9. - PubMed