Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2022 Sep 1;43(9):995-1003.
doi: 10.1097/MNM.0000000000001605. Epub 2022 Aug 10.

Effect of vitamin E and supragingival scaling on salivary gland function in patients with differentiated thyroid cancer treated with 131I

Yan Cheng  1 , Huimin Tong  1 , Xiaoqian Li  1 , Xiaomin Zhang  2 , Ju Fang  1 , Rongli Yue  1 , Nan Huang  1 , Jing Tian  1 , Feiyan Yu  3 , Ying Gao  2
Affiliations
Randomized Controlled Trial

Effect of vitamin E and supragingival scaling on salivary gland function in patients with differentiated thyroid cancer treated with 131I

Yan Cheng et al. Nucl Med Commun. .

Abstract

Objective: The aim of this study was to evaluate the effect of vitamin E and supragingival scaling with vitamin C on the salivary glands of patients with differentiated thyroid carcinoma after 131I treatment.

Methods: A total of 89 prospective patients with differentiated thyroid carcinoma were enrolled and randomly divided into the following groups: vitamin E group (n = 30, group A), vitamin C group (n = 30, group B) and supragingival scaling with vitamin C group (n = 29, group C). Using functional indices (e.g. maximum uptake fraction, uptake index, excretion fraction, secretion time and excretion rate), changes in the salivary gland functions before and a month after 131I treatment were assessed by dynamic imaging of salivary gland.

Results: We compared the before and after 131I therapy results of the three groups. In group A (P < 0.05), the excretion fraction and excretion rate of the left parotid gland were significantly higher, and the uptake index of the bilateral submandibular glands was significantly lower. No significant changes in salivary gland functional parameters were observed in group B (P > 0.05). The uptake index of the bilateral parotid glands and the excretion rate of the left parotid gland were significantly higher in group C (P < 0.05). The degree of serum amylase level reduction decreased significantly in group C (P < 0.05).

Conclusion: Vitamin E showed a protective effect on parotid excretion function in patients with differentiated thyroid carcinoma who underwent 131I treatment. Supragingival scaling may be a promising radiation protector because it is associated with a protective effect on the salivary gland functions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Hariharan S, Dharmaraj S. Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology 2020; 28:667–695.
    1. Sisto M, Lorusso L, Ingravallo G, Nico B, Ribatti D, Ruggieri S, et al. Abnormal distribution of AQP4 in minor salivary glands of primary Sjögren’s syndrome patients. Autoimmunity 2017; 50:202–210.
    1. Araujo MVT, Spadella MA, Chies AB, Arruda GV, Santos TM, Cavariani MM, Domeniconi RF. Effect of low radiation dose on the expression and location of aquaporins in rat submandibular gland. Tissue Cell 2018; 53:104–110.
    1. Kakoei S, Nekouei AH, Kakooei S, Najafipour H. The effect of demographic characteristics on the relationship between smoking and dry mouth in Iran: a cross-sectional, case-control study. Epidemiol Health 2021; 43:e2021017.
    1. Stewart CR, Obi N, Epane EC, Akbari AA, Halpern L, Southerland JH, Gangula PR. Effects of diabetes on salivary gland protein expression of tetrahydrobiopterin and nitric oxide synthesis and function. J Periodontol 2016; 87:735–741.

Publication types