WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation

Aleksandra Sejda¹, Wiesława Grajkowska², Joanna Trubicka², Ewa Szutowicz³, Tomasz Wojdacz⁴, Wojciech Kloc^{5

6}, Ewa Iżycka-Świeszewska^{7

8}

Affiliations

¹ Department of Pathomorphology and Forensic Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
² Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
³ Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.
⁴ Independent Clinical Epigenetics Laboratory, Pomeranian Medical University in Szczecin, Poland.
⁵ Department of Neurosurgery, Copernicus Hospital in Gdansk, Poland.
⁶ Department of Psychology, Health Sociology and Public Health School, University of Warmia and Mazury, Olsztyn.
⁷ Department of Pathology and Neuropathology, Medical University of Gdansk, Gdansk, Poland.
⁸ Department of Pathomorphology, Copernicus Hospital in Gdansk, Poland.

PMID: 35950467
DOI: 10.5114/fn.2022.118183

Free article

Review

WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation

Aleksandra Sejda et al. Folia Neuropathol. 2022.

Free article

. 2022;60(2):137-152.

doi: 10.5114/fn.2022.118183.

Authors

Aleksandra Sejda¹, Wiesława Grajkowska², Joanna Trubicka², Ewa Szutowicz³, Tomasz Wojdacz⁴, Wojciech Kloc^{5

6}, Ewa Iżycka-Świeszewska^{7

8}

Affiliations

¹ Department of Pathomorphology and Forensic Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
² Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
³ Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.
⁴ Independent Clinical Epigenetics Laboratory, Pomeranian Medical University in Szczecin, Poland.
⁵ Department of Neurosurgery, Copernicus Hospital in Gdansk, Poland.
⁶ Department of Psychology, Health Sociology and Public Health School, University of Warmia and Mazury, Olsztyn.
⁷ Department of Pathology and Neuropathology, Medical University of Gdansk, Gdansk, Poland.
⁸ Department of Pathomorphology, Copernicus Hospital in Gdansk, Poland.

PMID: 35950467
DOI: 10.5114/fn.2022.118183

Abstract

The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours classification has transformed the pathological diagnosis of gliomas from purely histological to the multilayered integrated one with molecular biomarkers necessary for proper classification, risk stratification, and prognostic-predictive clinical purposes. Because of deep and important changes in taxonomy and diagnostic approach to gliomas, this manuscript is a review of WHO CNS classification 5th edition with general testing guidance for pathologists and clinicians working in neuro-oncology.

Keywords: 5th edition; WHO; classification; neuropathology; gliomas.

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WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation

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WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation

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