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. 2025 Aug;10 Suppl 1(Suppl 1):S183-S205.
doi: 10.1002/epi4.12640. Epub 2022 Sep 9.

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force

Erwin A van Vliet  1   2 , Michael S Hildebrand  3   4 , James D Mills  2 , Gary P Brennan  5   6 , Tore Eid  7 , Susan A Masino  8 , Vicky Whittemore  9 , Laura Bindila  10 , Kevin K Wang  11   12 , Manisha Patel  13 , Piero Perucca  3   14   15   16   17 , Christopher A Reid  3   4   18
Affiliations

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force

Erwin A van Vliet et al. Epilepsia Open. 2025 Aug.

Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research-related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics, and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics, and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two-part series of omics papers with the second installment to cover proteomics, lipidomics, and metabolomics in adult rodents.

Keywords: common data elements; mouse; omic data processing; preclinical; rat.

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Conflict of interest statement

MP and PP are Associate Editors for Epilepsia Open. None of the other authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

FIGURE 1
FIGURE 1
Flowchart of omics‐based studies
FIGURE 2
FIGURE 2
Sample collection and storage case report form (CRF; see main text for details)
FIGURE 3
FIGURE 3
Genomics, transcriptomics, and epigenomics case report form (CRF; see main text for details)
See this image and copyright information in PMC

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