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. 2022 Oct;40(9):750-759.
doi: 10.1080/07357907.2022.2112693. Epub 2022 Aug 21.

Dynamics of the Immune Response in Hospitalized SARS-CoV-2-infected Cancer Patients

Mateus Nóbrega Aoki  1 , Jeanine Marie Nardin  2 , Luciano Fernandes Huergo  3 , Lucas Blanes  1 , Hugo Manuel Paz Morales  2 , Bruna Fornazari  2 , Marcelo Santos Conzentino  3 , Maria Eduarda Alencar Migliorini  2 , Dalila Lucíola Zanette  1
Affiliations

Dynamics of the Immune Response in Hospitalized SARS-CoV-2-infected Cancer Patients

Mateus Nóbrega Aoki et al. Cancer Invest. 2022 Oct.

Abstract

Seroconversion rates were compared between oncological and nononcological patients infected with SARS-CoV-2 during a 14-day hospitalization time. All COVID-19 non-oncological and solid malignancies patients reached 100% seroconversion at day 14, while less than half of the hematological patients were seroconverted at the same time point. Despite the limited number and variability of the patient's cohort, we conclude that there is a delayed seroconversion in the hematological malignancies group, which may be linked to changes in the hematological parameters, immune suppression and/or oncological treatments that are typically associated with these patients.

Keywords: COVID-19; IgG antibodies; cancer; immunity; seroconversion.

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