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. 2023 Feb;55(2):389-398.
doi: 10.1007/s11255-022-03328-9. Epub 2022 Aug 11.

Investigation on maintenance hemodialysis patients with mineral and bone disorder in Anhui province, China

Shuman Tao  1 , Xiuyong Li  2 , Zhi Liu  3 , Youwei Bai  4 , Guangrong Qian  5 , Han Wu  6 , Ji Li  7 , Yuwen Guo  8 , Shanfei Yang  9 , Lei Chen  10 , Jian Yang  11 , Jiuhuai Han  12 , Shengyin Ma  13 , Jing Yang  14 , Linfei Yu  15 , Runzhi Shui  16 , Xiping Jin  17 , Hongyu Wang  18 , Fan Zhang  19 , Tianhao Chen  20 , Xinke Li  21 , Xiaoying Zong  22 , Li Liu  23 , Jihui Fan  24 , Wei Wang  25 , Yong Zhang  26 , Guangcai Shi  27 , Deguang Wang  28
Affiliations

Investigation on maintenance hemodialysis patients with mineral and bone disorder in Anhui province, China

Shuman Tao et al. Int Urol Nephrol. 2023 Feb.

Abstract

Background: Chronic kidney disease-mineral bone disorder (CKD-MBD) is a common comorbidity in patients with CKD. The study aims to describe the control rates of serum-corrected calcium (Ca), phosphate (P) and intact parathyroid hormone (iPTH) and its risk factors among maintenance hemodialysis (MHD) patients in Anhui Province of China.

Methods: The study was conducted in 27 hemodialysis centers of Anhui Province between January 1st 2020 and December 31th 2020. Chi-square test was used to compare the control rates of serum-corrected Ca, P and iPTH between the present study and DOPPS 4 or Anhui Province in 2014. Binary logistic regression analysis was used to explore the risk factors of the control rates of serum-corrected Ca, P and iPTH.

Results: A total of 3 025 MHD patients were recruited in this study, with a mean age of 54.8 (SD: 12.8) years, and 60.1% were males. According to the Chinese Diagnosis and Treatment Guidelines for CKD-MBD, the control rates of serum-corrected Ca, P and iPTH in the present study were 57.9%, 20.0% and 56.0%, respectively. Based on KDOQI guidelines (2003), the control rates of the above indicators were 43.1%, 35.3% and 22.3%, respectively. The control rates of serum-corrected Ca, P and iPTH in this study were lower than those of DOPPS 4 (P < 0.001). Compared to the results of Anhui Province in 2014, the control rate of corrected Ca was higher (P < 0.001) and the control rate of iPTH was lower (P = 0.005). Age, residential area, BMI, dialysis vintage, albumin and hemoglobin levels were factors of serum-corrected Ca, P and iPTH not within target range.

Conclusion: The control rates of serum-corrected Ca, P and iPTH in MHD patients in Anhui Province are relatively low. Monitoring and management should be strengthened to improve the prognosis of patients undergoing dialysis.

Keywords: Chronic kidney disease; Hemodialysis; Mineral and bone disorder.

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