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Review
. 2023 Jun;25(2):163-178.
doi: 10.1007/s12017-022-08724-z. Epub 2022 Aug 11.

Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies

Chandra Prakash  1 , Jyoti Tyagi  1 , Shyam Sunder Rabidas  1 , Vijay Kumar  2 , Deepak Sharma  3
Affiliations
Review

Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies

Chandra Prakash et al. Neuromolecular Med. 2023 Jun.

Abstract

Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. Quercetin and its derivatives like rutin and hyperoside are known for their beneficial effects in various neurological conditions including epilepsy. The clinical studies of quercetin and its derivatives in relation to epilepsy are limited. This review provides the evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies. Additionally, the studies demonstrating antiseizure potential of various plants extracts enriched with quercetin and its derivatives has been included in this review. Herein, we have also discussed neuroprotective effect of these bioactive compound and presented underlying mechanisms responsible for anticonvulsant properties in brief. Finally, limitations of quercetin and its derivatives as antiseizure compounds as well as possible strategies to enhance efficacy have also been discussed.

Keywords: Anticonvulsant properties; Antiseizure effect; Epileptic seizures; Plant extracts; Quercetin; Quercetin derivatives.

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