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. 2022 Aug 10;30(8):1070-1071.
doi: 10.1016/j.chom.2022.07.005.

To err is human, to forgive may require different vaccines

C Buddy Creech  1
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Free article

To err is human, to forgive may require different vaccines

C Buddy Creech. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Tsai et al. (2022) provide evidence that Staphylococcus aureus should be numbered among the pathogens for which original antigenic sin governs subsequent immune responses. Their approach may restore the utility of murine models in staphylococcal vaccine development.

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Conflict of interest statement

Declaration of interests The author was a site investigator on the Merck V710 vaccine trial referenced in the work and has served as a consultant on staphylococcal vaccine development to GSK, Pfizer, Novadigm, and Novartis. He is a co-inventor for a human monoclonal antibody for S. aureus (US Patent No. 10981979).

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