Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Sep;43(9):690-692.
doi: 10.1016/j.it.2022.07.008. Epub 2022 Aug 9.

ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities

Sophie Curio  1 , Gabrielle T Belz  2
Affiliations
Comment

ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities

Sophie Curio et al. Trends Immunol. 2022 Sep.

Abstract

Group 3 innate lymphoid cells (ILC3s) are distributed along the gastrointestinal tract at the interface between the immune system and the gut lumen, which carries a significant microbial burden. In a new study, Zhou et al. investigated the expression of transcription factor ZBTB46, normally thought to be restricted to classical dendritic cells (cDCs), and discovered that ZBTB46 expression by ILC3s in the mouse colon forms an essential part of the gastrointestinal armory to calibrate inflammatory responses.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

Publication types

Substances

LinkOut - more resources