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Comment
. 2022 Oct;33(10):665-667.
doi: 10.1016/j.tem.2022.07.005. Epub 2022 Aug 8.

Location matters: hexokinase 1 in glucose metabolism and inflammation

Sivaraj M Sundaram  1 , Luke A Doughty  2 , Michael W Sereda  3
Affiliations
Comment

Location matters: hexokinase 1 in glucose metabolism and inflammation

Sivaraj M Sundaram et al. Trends Endocrinol Metab. 2022 Oct.

Abstract

Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.

Keywords: aging; deacetylation; diabetes; glucose metabolism; inflammation; nitrosylation.

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Comment on

  • Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
    De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H. De Jesus A, et al. Mol Cell. 2022 Apr 7;82(7):1261-1277.e9. doi: 10.1016/j.molcel.2022.02.028. Epub 2022 Mar 18. Mol Cell. 2022. PMID: 35305311 Free PMC article.

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