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. 2022 Oct;596(20):2659-2667.
doi: 10.1002/1873-3468.14468. Epub 2022 Aug 19.

The immunoreceptor SLAMF8 promotes the differentiation of follicular dendritic cell-dependent monocytic cells with B cell-activating ability

Masaki Magari  1   2 , Miku Nishioka  1 , Tomomi Hari  1 , Sayaka Ogawa  2 , Kaho Takahashi  1 , Naoya Hatano  1 , Naoki Kanayama  1   2 , Junichiro Futami  3 , Hiroshi Tokumitsu  1   2
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Free article

The immunoreceptor SLAMF8 promotes the differentiation of follicular dendritic cell-dependent monocytic cells with B cell-activating ability

Masaki Magari et al. FEBS Lett. 2022 Oct.
Free article

Abstract

Follicular dendritic cells (FDCs) play a crucial role in generating high-affinity antibody-producing B cells during the germinal center (GC) reaction. Herein, we analysed the altered gene expression profile of a mouse FDC line, FL-Y, following lymphotoxin β receptor stimulation, and observed increased Slam-family member 8 (Slamf8) mRNA expression. Forced Slamf8 expression and SLAMF8-Fc addition enhanced the ability of FL-Y cells to induce FDC-induced monocytic cell (FDMC) differentiation. FDMCs accelerated GC-phenotype proliferation in cultured B cells, suggesting that they are capable of promoting GC responses. Furthermore, a pulldown assay showed that SLAMF8-Fc could bind to SLAMF8-His. Overall, the homophilic interaction of SLAMF8 promotes FDMC differentiation and SLAMF8 might act as a novel regulator of GC responses by regulating FDMC differentiation.

Keywords: SLAMF8; follicular dendritic cell; follicular dendritic cell-induced monocytic cell; germinal center; lymphotoxin; lymphotoxin β receptor.

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