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. 2022 Dec;24(12):2441-2452.
doi: 10.1007/s12094-022-02915-7. Epub 2022 Aug 11.

The prognostic significance of different degrees of resection of skull base chordoma

Yaxuan Wang  1   2   3   4 , Zhouying Peng  1   2   3   4 , Yumin Wang  1   2   3   4 , Ruohao Fan  1   2   3   4 , Hua Zhang  1   2   3   4 , Weihong Jiang  5   6   7   8
Affiliations

The prognostic significance of different degrees of resection of skull base chordoma

Yaxuan Wang et al. Clin Transl Oncol. 2022 Dec.

Abstract

Background: Complete resection combined with postoperative radiotherapy is ideal for skull base chordomas. The recent literature suggests that the degree of surgical resection is the most important prognostic factor.

Methods: We retrospectively analyzed the clinical data of 16 patients with initial chordoma treated at our center between August 2015 and December 2021 and conducted a retrospective study on the prognosis of surgical treatment of skull base chordoma between 2013 and 2022.

Results: According to the Kaplan-Meier method, there was a significant difference in PFS between patients aged > 50 years and < 50 years, and no significant difference was observed in PFS for tumor involvement of the internal carotid artery, dura, or superior or inferior clivus. However, there was still a correlation with prognosis. As observed in the included literature, the 5-year overall survival rate was significantly higher in patients undergoing total skull base chordoma resection than in those undergoing subtotal resection (STR), which in turn was significantly higher than in those undergoing partial resection (PR). Patients undergoing subtotal resection had significantly better 5-year PFS rates than those undergoing PR.

Conclusion: Our study shows that gross total resection and STR have better survival in patients with skull base chordomas compared to PR.

Keywords: Chordoma; Gross total resection; Partial resection; Prognosis; Subtotal resection.

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