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. 2022 Aug 6;12(15):1993.
doi: 10.3390/ani12151993.

Locally Injected Autologous Platelet-Rich Plasma Improves Cutaneous Wound Healing in Cats

Vasileia Angelou  1 , Dimitra Psalla  2 , Chrysostomos I Dovas  3 , George M Kazakos  4 , Christina Marouda  2 , Kyriakos Chatzimisios  1 , Zacharenia Kyrana  5 , Evangelia Moutou  3 , Maria Karayannopoulou  1 , Lysimachos G Papazoglou  1
Affiliations

Locally Injected Autologous Platelet-Rich Plasma Improves Cutaneous Wound Healing in Cats

Vasileia Angelou et al. Animals (Basel). .

Abstract

Cutaneous defects in cats are commonly encountered in clinical practice, and healing can be accomplished by first or second intention. Platelet-rich plasma (PRP) is characterized by a plasma concentration containing a large number of platelets in a small volume of plasma. The objective of the present study was to record the efficacy of PRP infiltration in open wounds in laboratory cats. Six wounds were created in the dorsal midline of eight laboratory cats, with the wounds of one side designated as the PRP group and the wounds of the other side as the control group. Wound healing was evaluated by daily clinical examination, planimetry, laser Doppler flowmetry, and histologic examination on days 0, 7, 14, and 25, and by measurement of metalloproteinases (MMPs)-2 and -9 and tissue inhibitor metalloproteinase (TIMP)-1 on days 0, 14, and 25. Based on the results of the present study, the mean time for full coverage with granulation tissue was shorter in the PRP group, the mean contraction and total wound healing percentage were increased compared to the control group, and finally, the perfusion measured with laser Doppler flowmetry was higher in the PRP group during all examination days. In conclusion, this is the first study focusing on the topical application of PRP in the treatment of open wounds in laboratory cats, and our results are encouraging-showing a more rapid healing in the PRP group.

Keywords: cat; laser Doppler flowmetry; metalloproteinases; platelet-rich plasma; wound.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The six wounds created on each cat.
Scheme 1
Scheme 1
A: Area between normal skin and epithelium. B: Epithelialization area (B = A − C). C: Open wound (area between epithelium and open wound).
Figure 2
Figure 2
PRP wounds during different measurement times (days 0, 7, 14, 25).
Figure 3
Figure 3
Control wounds during different measurement times (days 0, 7, 14, 25).
See this image and copyright information in PMC

References

    1. Mitsui A., Mathews K.G., Linder K.E., Kruse M.A., Roe S.C. Effects of fascial abrasion, fasciotomy, and fascial excision on cutaneous wound healing in cats. Am. J. Vet. Res. 2009;70:532–538. doi: 10.2460/ajvr.70.4.532. - DOI - PubMed
    1. Bohling M.W., Henderson R.A. Differences in cutaneous wound healing between dogs and cats. Vet. Clin. North Am. Small Anim. Pract. 2006;36:687–692. doi: 10.1016/j.cvsm.2006.02.001. - DOI - PubMed
    1. Bohling M.W., Henderson R.A., Swaim S.F., Kincaid S.A., Wright J.C. Comparison of the role of the subcutaneous tissues in cutaneous wound healing in the dog and cat. Vet. Surg. 2006;35:3–14. doi: 10.1111/j.1532-950X.2005.00105.x. - DOI - PubMed
    1. Affolter V.K., Moore P.F. Histologie features of normal canine and feline skin. Clin. Dermatol. 1994;12:491–497. doi: 10.1016/0738-081X(94)90215-1. - DOI - PubMed
    1. Taylor G.I., Minabe T. The angiosomes of the mammals and other vertebrates. Plast. Reconstr. Surg. 1992;89:181–215. doi: 10.1097/00006534-199202000-00001. - DOI - PubMed