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Review
. 2022 Jul 28;14(15):3663.
doi: 10.3390/cancers14153663.

A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology

Maroun Bou Zerdan  1   2 , Lewis Nasr  3 , Ludovic Saba  3 , Paul Meouchy  4 , Nadine Safi  4 , Sabine Allam  5 , Jenish Bhandari  1 , Chakra P Chaulagain  2
Affiliations
Review

A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology

Maroun Bou Zerdan et al. Cancers (Basel). .

Abstract

Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma.

Keywords: chimeric antigen receptor T-cell therapy; clonal hematopoeisis; hematology; mutations; myeloma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the different mutations involved in CHIP.
See this image and copyright information in PMC

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