Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 5;14(15):3814.
doi: 10.3390/cancers14153814.

The Role of [68Ga]Ga-Pentixafor PET/CT or PET/MRI in Lymphoma: A Systematic Review

Domenico Albano  1   2 , Francesco Dondi  1 , Francesco Bertagna  1   2 , Giorgio Treglia  3   4   5
Affiliations
Review

The Role of [68Ga]Ga-Pentixafor PET/CT or PET/MRI in Lymphoma: A Systematic Review

Domenico Albano et al. Cancers (Basel). .

Abstract

The aim of this systematic review was to investigate published data about the role of gallium-68 Pentixafor positron emission tomography/computed tomography ([68Ga]Ga-Pentixafor PET/CT) or PET/magnetic resonance imaging (PET/MRI) in patients affected by lymphoma. A comprehensive computer literature search of the Scopus, PubMed/MEDLINE, and Embase databases was conducted including articles indexed up to June 2022. In total, 14 studies or subsets in studies were eligible for inclusion. From the analyses of the selected studies, the following main findings have been found: (1) lymphomas can be considered [68Ga]Ga-Pentixafor avid diseases, also in cases of fluorine-18 fluorodeoxyglucose [18F]FDG-not avid forms such as lymphoplasmacytic lymphoma (LPL), chronic lymphocytic leukemia (CLL), marginal zone lymphoma (MZL) and central nervous system lymphoma (CNSL); (2) among lymphomas, mantle cell lymphoma (MCL) and MZL are those with highest [68Ga]Ga-Pentixafor uptake; (3) [68Ga]Ga-Pentixafor PET/CT or PET/MRI is a useful tool for the staging and treatment response evaluation; (4) [68Ga]Ga-Pentixafor PET seems to have a better diagnostic performance than [18F]FDG PET in evaluating lymphomas. Despite several limitations affecting this analysis, especially related to the heterogeneity of the included studies, [68Ga]Ga-Pentixafor PET may be considered a useful imaging method for staging and treatment response evaluation of several lymphomas, especially MZL, CNSL and LPL.

Keywords: CXCR4; PET/CT; PET/MRI; Pentixafor; gallium-68; lymphoma; nuclear medicine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA literature search flow-chart.
Figure 2
Figure 2
Quadas 2 score of the studies included in the review.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Colobran R., Pujol-Borrell R., Armengol M.P., Juan M. The chemokine network. I. How the genomic organization of chemokines contains clues for deciphering their functional complexity. Clin. Exp. Immunol. 2007;148:208–217. doi: 10.1111/j.1365-2249.2007.03344.x. - DOI - PMC - PubMed
    1. Balkwill F. Cancer and the chemokine network. Nat. Rev. Cancer. 2004;4:540–550. doi: 10.1038/nrc1388. - DOI - PubMed
    1. Chatterjee S., Behnam Azad B., Nimmagadda S. The intricate role of CXCR4 in cancer. Adv. Cancer Res. 2014;124:31–82. - PMC - PubMed
    1. Buck A.K., Serfling S.E., Lindner T., Hänscheid H., Schirbel A., Hahner S., Fassnacht M., Einsele H., Werner R.A. CXCR4-targeted theranostics in oncology. Eur. J. Nucl. Med. Mol. Imaging. 2022 doi: 10.1007/s00259-022-05849-y. online ahead of print . - DOI - PMC - PubMed
    1. Mayerhoefer M.E., Archibald S.J., Messiou C., Staudenherz A., Berzaczy D., Schöder H. MRI and PET/MRI in hematologic malignancies. J. Magn. Reason. Imaging. 2020;51:1325–1335. doi: 10.1002/jmri.26848. - DOI - PMC - PubMed

LinkOut - more resources