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Review
. 2022 Jul 27;23(15):8278.
doi: 10.3390/ijms23158278.

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Jelena Roganović  1 , Nina Petrović  2   3
Affiliations
Review

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Jelena Roganović et al. Int J Mol Sci. .

Abstract

Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based on ncRNAs' suitability for salivary biomarkers and their involvement in neuropathic pain and tissue regeneration signaling pathways, the present narrative review aims to highlight the potential clinical applications of ncRNAs in oral inflammatory diseases, with an emphasis on salivary diagnostics, regenerative dentistry, and precision medicine for neuropathic orofacial pain.

Keywords: neuropathic pain; non-coding RNA; oral inflammatory diseases; precision medicine; regenerative dentistry; salivary diagnostics.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or data interpretation; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Clinical perspectives of ncRNAs in precision medicine of oral inflammatory diseases.
Figure 2
Figure 2
The scheme of ncRNAs with potential for regenerative dentistry. ncRNAs labeled in green promote while ncRNAs labeled in red inhibit osteogenic/odontogenic differentiation of stem cells.
Figure 3
Figure 3
ncRNA in precision medicine for orofacial neuropathic pain. ncRNA interplay between injury/inflammation and neuropathy development could be used in diagnosis/prediction and in patient-tailored treatments as an integral part of precision medicine for neuropathic pain.
See this image and copyright information in PMC

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