Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 27;23(15):8278.
doi: 10.3390/ijms23158278.

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Jelena Roganović  1 , Nina Petrović  2   3
Affiliations
Review

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Jelena Roganović et al. Int J Mol Sci. .

Abstract

Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based on ncRNAs' suitability for salivary biomarkers and their involvement in neuropathic pain and tissue regeneration signaling pathways, the present narrative review aims to highlight the potential clinical applications of ncRNAs in oral inflammatory diseases, with an emphasis on salivary diagnostics, regenerative dentistry, and precision medicine for neuropathic orofacial pain.

Keywords: neuropathic pain; non-coding RNA; oral inflammatory diseases; precision medicine; regenerative dentistry; salivary diagnostics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or data interpretation; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Clinical perspectives of ncRNAs in precision medicine of oral inflammatory diseases.
Figure 2
Figure 2
The scheme of ncRNAs with potential for regenerative dentistry. ncRNAs labeled in green promote while ncRNAs labeled in red inhibit osteogenic/odontogenic differentiation of stem cells.
Figure 3
Figure 3
ncRNA in precision medicine for orofacial neuropathic pain. ncRNA interplay between injury/inflammation and neuropathy development could be used in diagnosis/prediction and in patient-tailored treatments as an integral part of precision medicine for neuropathic pain.
See this image and copyright information in PMC

References

    1. Shankpiece F.A., Cantos A. Oral Inflammation and Infection, and Chronic Medical Diseases: Implications for the Elderly. Periodontology 2000. 2016;72:153–175. doi: 10.1111/prd.12129. - DOI - PubMed
    1. ENCODE Project Consortium An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 2012;489:57–74. doi: 10.1038/nature11247. - DOI - PMC - PubMed
    1. Angrand P.-O., Vennin C., Le Bourhis X., Adriaenssens E. The Role of Long Non-Coding RNAs in Genome Formatting and Expression. Front. Genet. 2015;6:165. doi: 10.3389/fgene.2015.00165. - DOI - PMC - PubMed
    1. Diamantopoulos M.A., Tsiakanikas P., Scorilas A. Non-Coding RNAs: The Riddle of the Transcriptome and Their Perspectives in Cancer. Ann. Transl. Med. 2018;6:241. doi: 10.21037/atm.2018.06.10. - DOI - PMC - PubMed
    1. Cabili M.N., Dunagin M.C., McClanahan P.D., Biaesch A., Padovan-Merhar O., Regev A., Rinn J.L., Raj A. Localization and Abundance Analysis of Human LncRNAs at Single-Cell and Single-Molecule Resolution. Genome Biol. 2015;16:20. doi: 10.1186/s13059-015-0586-4. - DOI - PMC - PubMed

LinkOut - more resources