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Review
. 2022 Jul 27;11(15):4365.
doi: 10.3390/jcm11154365.

Clostridioides difficile Infection in Patients after Organ Transplantation-A Narrative Overview

Sylwia Dudzicz-Gojowy  1 , Andrzej Więcek  1 , Marcin Adamczak  1
Affiliations
Review

Clostridioides difficile Infection in Patients after Organ Transplantation-A Narrative Overview

Sylwia Dudzicz-Gojowy et al. J Clin Med. .

Abstract

Clostridioides difficile infection (CDI) is one of the most common causes of antibiotic-associated diarrhea. The pathogenesis of this infection participates in the unstable colonization of the intestines with the physiological microbiota. Solid-organ-transplant (SOT) patients and patients after hematopoietic stem cell transplantation are more prone to CDI compared to the general population. The main CDI risk factors in these patients are immunosuppressive therapy and frequent antibiotic use leading to dysbiosis. The current review article provides information about the risk factors, incidence and course of CDI in patients after liver, kidney, heart and lung transplantation and hematopoietic stem cell transplantation.

Keywords: Clostridioides difficile infection; hematopoietic stem cell transplantation; solid-organ transplantation.

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Conflict of interest statement

Marcin Adamczak received a lecturer fee from Sanprobi. The other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Therapy of Clostridioides difficile infection (i.v.–intravenous, p.o.–per os) [22].
See this image and copyright information in PMC

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