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. 2022 Jul 28;11(15):4382.
doi: 10.3390/jcm11154382.

Anemia-Associated Platelets and Plasma Prothrombin Time Increase in Patients with Adenomyosis

Qiao Lin  1   2 , Tiantian Li  1 , ShaoJie Ding  1 , Qin Yu  1 , Xinmei Zhang  1
Affiliations

Anemia-Associated Platelets and Plasma Prothrombin Time Increase in Patients with Adenomyosis

Qiao Lin et al. J Clin Med. .

Abstract

Patients with adenomyosis are hypercoagulable and often accompanied by anemia, but the specific changes in anemia-related coagulation parameters are still unclear. This study investigated the changes in and influencing factors of coagulation parameters related to anemia in patients with adenomyosis (AM). The coagulation parameters, including platelet count (PC), plasma prothrombin time (PT), activated partial prothrombin time (APTT), thrombin time (TT) and fibrinogen (FB), and hemoglobin (Hb), were measured in patients with adenomyosis (229 cases in AM group), uterine leiomyoma (265 cases in LM group), and undergoing tubal anastomosis (142 cases in the control group). The age of the control group was younger than that of the AM group and the LM group. Compared with the AM and LM groups, the uterus size of the control group was smaller; the AM group was larger than the LM group. The Hb concentration of the AM group was lower than that of the LM and control groups. Compared with the LM and control groups, PC increased and TT shortened in the AM group. APTT in the AM group was shorter than in the control group, and PT was longer than in the LM group. After adjustment using multiple logistic regression analysis, adenomyosis was correlated with Hb concentration (or = 0.971, 95% CI 0.954−0.988, p < 0.001), PC (or = 1.006, 95% CI 1.002−1.011, p = 0.004), PT (or = 3.878, 95% CI 2.347−6.409, p < 0.001), age (or = 1.062, 95% CI 1.013−1.114, p = 0.013), and uterine size (or = 1.103, 95% CI 1.011−1.203, p = 0.028). Correlation analysis showed that PC (r = −0.309) and PT (r = −0.252) were negatively correlated with anemia. The increase in Hb-related PC and PT in patients with adenomyosis indicates that the timely and early detection of coagulation parameters is needed for patients with severe anemia, older age, and larger uterine volume.

Keywords: adenomyosis; anemia; coagulation parameters; platelets.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Comparisons of coagulation parameters between groups (median and range). (a) Comparison of platelet count (PC) between groups; (b) Comparison of plasm a prothrombin time (PT) between groups; (c) Comparison of activated partial prothrombin time (APTT) between groups; (d) Comparison of thrombin time (TT) between groups. *, p < 0.025 (compared with the AM group).
Figure 3
Figure 3
Correlations of PC and PT with hemoglobin PC, platelet count; PT, plasma prothrombin time.
Figure 4
Figure 4
Receiver-operating characteristic curves of PC and PT for the diagnosis of adenomyosis.
See this image and copyright information in PMC

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