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Review
. 2022 Jul 28;11(15):4405.
doi: 10.3390/jcm11154405.

The Impact of Mental Stress on Cardiovascular Health-Part II

Affiliations
Review

The Impact of Mental Stress on Cardiovascular Health-Part II

Michael Y Henein et al. J Clin Med. .

Abstract

Endothelial dysfunction is one of the earliest manifestations of atherosclerosis, contributing to its development and progression. Mental stress induces endothelial dysfunction through increased activity of the sympathetic nervous system, release of corticotropin-releasing hormone from the hypothalamus, inhibition of nitric oxide (NO) synthesis by cortisol, and increased levels of pro-inflammatory cytokines. Mental-stress-induced increased output of the sympathetic nervous system and concomitant withdrawal of the parasympathetic inflammatory reflex results in systemic inflammation and activation of a neural-hematopoietic-arterial axis. This includes the brainstem and subcortical regions network, bone marrow activation, release of leukocytes into the circulation and their migration to the arterial wall and atherosclerotic plaques. Low-grade, sterile inflammation is involved in all steps of atherogenesis, from coronary plaque formation to destabilisation and rupture. Increased sympathetic tone may cause arterial smooth-muscle-cell proliferation, resulting in vascular hypertrophy, thus contributing to the development of hypertension. Emotional events also cause instability of cardiac repolarisation due to brain lateralised imbalance of cardiac autonomic nervous stimulation, which may lead to asymmetric repolarisation and arrhythmia. Acute emotional stress can also provoke severe catecholamine release, leading to direct myocyte injury due to calcium overload, known as myocytolysis, coronary microvascular vasoconstriction, and an increase in left ventricular afterload. These changes can trigger a heart failure syndrome mimicking acute myocardial infarction, characterised by transient left ventricular dysfunction and apical ballooning, known as stress (Takotsubo) cardiomyopathy. Women are more prone than men to develop mental-stress-induced myocardial ischemia (MSIMI), probably reflecting gender differences in brain activation patterns during mental stress. Although guidelines on CV prevention recognise psychosocial factors as risk modifiers to improve risk prediction and decision making, the evidence that their assessment and treatment will prevent CAD needs further evaluation.

Keywords: Takotsubo; arrhythmia; endothelial dysfunction; hypertension; mental stress; systemic inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic model of the mechanisms that translate negative emotion into CV disease. The brain response to mental stress involves activation of autonomic nervous system, hypothalamic–pituitary–adrenal axis, and neural–hematopoietic–arterial axis, resulting in pathophysiological effects that trigger CV events (brain-to-body). In turn, these effects modulate the brain response to stress (body-to-brain).
Figure 2
Figure 2
A 73-year-old woman admitted for anterior ST-elevation myocardial infarction. Coronary angiography showed no coronary lesions on left and right coronary arteries (frames (1) and (2)). Left ventriculogram (frames (3) and (4)) showed typical ballooning of the left ventricle apex (frame (4)), characterised by hypercontraction of the basal segments (with asterisks) and akinesia in the mid and apical segments (with arrows), typical for Takotsubo cardiomyopathy.
Figure 3
Figure 3
A 43-year-old man admitted for anterior ST-elevation myocardial infarction. Coronary angiography showed no coronary lesions on left and right coronary arteries (frames (1) and (2)). Left ventriculogram (frames (3) and (4)) showed hypercontraction of the basal segments and apex (frame (4), with asterisks) and akinesia in the mid segments (with arrows), typical for mid-ventricular Takotsubo cardiomyopathy.

References

    1. Yusuf S., Hawken S., Ôunpuu S., Dans T., Avezum A., Lanas F., McQueen M., Budaj A., Pais P., Varigos J., et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-Control study. Lancet. 2004;364:937–952. doi: 10.1016/S0140-6736(04)17018-9. - DOI - PubMed
    1. Rosengren A., Hawken S., Ôunpuu S., Sliwa K., Zubaid M., Almahmeed W.A., Blackett K.N., Sitthi-amorn C., Sato H., Yusuf S. Association of psychosocial risk factors with risk of acute myocardial infarction in 11,119 cases and 13,648 controls from 52 countries (the INTERHEART study): Case-Control study. Lancet. 2004;364:953–962. doi: 10.1016/S0140-6736(04)17019-0. - DOI - PubMed
    1. Mostofsky E., Penner E.A., Mittleman M.A. Outbursts of anger as a trigger of acute cardiovascular events: A systematic review and meta-analysis. Eur. Heart J. 2014;35:1404–1410. doi: 10.1093/eurheartj/ehu033. - DOI - PMC - PubMed
    1. Rozanski A. Behavioral Cardiology: Current Advances and Future Directions. J. Am. Coll. Cardiol. 2014;64:100–110. doi: 10.1016/j.jacc.2014.03.047. - DOI - PubMed
    1. Vancheri F., Longo G., Vancheri E., Henein M.Y. Mental Stress and Cardiovascular Health. J. Clin. Med. 2022;11:3353. doi: 10.3390/jcm11123353. - DOI - PMC - PubMed

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