Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score-Matched Diabetes Cohort Study

Jui-An Lin^{1

2

3

4

5

6

7}, Jin-De Hou^{3

8}, Szu-Yuan Wu^{1

9

10

11

12

13

14

15

16}

Affiliations

¹ Center for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
² Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
³ Department of Anesthesiology, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
⁴ Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁵ Pain Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
⁶ Department of Anesthesiology, School of Medicine, Shung Shan Medical University, Taichung City 40201, Taiwan.
⁷ Department of Anesthesiology, Shung Shan Medical University Hospital, Taichung City 40201, Taiwan.
⁸ Division of Anesthesiology, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan.
⁹ Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 24205, Taiwan.
¹⁰ Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei 24205, Taiwan.
¹¹ Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
¹² Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹³ Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹⁴ Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
¹⁵ Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹⁶ Department of Management, College of Management, Fo Guang University, Yilan 262307, Taiwan.

PMID: 35956041
PMCID: PMC9369839
DOI: 10.3390/jcm11154424

Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score-Matched Diabetes Cohort Study

Jui-An Lin et al. J Clin Med. 2022.

. 2022 Jul 29;11(15):4424.

doi: 10.3390/jcm11154424.

Authors

Jui-An Lin^{1

2

3

4

5

6

7}, Jin-De Hou^{3

8}, Szu-Yuan Wu^{1

9

10

11

12

13

14

15

16}

Affiliations

¹ Center for Regional Anesthesia and Pain Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
² Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
³ Department of Anesthesiology, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
⁴ Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁵ Pain Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
⁶ Department of Anesthesiology, School of Medicine, Shung Shan Medical University, Taichung City 40201, Taiwan.
⁷ Department of Anesthesiology, Shung Shan Medical University Hospital, Taichung City 40201, Taiwan.
⁸ Division of Anesthesiology, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan.
⁹ Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 24205, Taiwan.
¹⁰ Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei 24205, Taiwan.
¹¹ Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
¹² Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹³ Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹⁴ Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
¹⁵ Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
¹⁶ Department of Management, College of Management, Fo Guang University, Yilan 262307, Taiwan.

PMID: 35956041
PMCID: PMC9369839
DOI: 10.3390/jcm11154424

Abstract

Purpose: The effect of sarcopenia on the survival of patients with type 2 diabetes remains unclear. Therefore, we designed a propensity score-matched population-based cohort study to compare the patients with diabetes with or without sarcopenia. Patients and Methods: We included patients with type 2 diabetes and categorized them into two groups according to whether they had sarcopenia and compared their survival; patients in the groups were matched at a ratio of 1:2. Results: The matching process yielded a final cohort of 201,698 patients (132,805 and 68,893 in the sarcopenia and nonsarcopenia diabetes groups, respectively) who were eligible for further analysis. According to both univariate and multivariate Cox regression analyses, the adjusted hazard ratios (aHRs; 95% confidence interval [CI]) of all-cause death for the sarcopenia diabetes group compared with the control group: 1.35 (1.33−1.38; p < 0.001). The aHRs (95% CIs) of all-cause death for those aged 41−50, 51−60, and >60 years (compared with those aged ≤40 years) were 1.53 (1.48−1.60), 2.61 (2.52−2.72), and 6.21 (5.99−6.45), respectively. The aHR (95% CI) of all-cause death for the male patients compared with the female patients was 1.56 (1.54−1.60). The aHRs (95% CIs) of all-cause death for those with adapted Diabetes Complications Severity Index (aDCSI) scores of 1, 2, 3, 4, and ≥5 (compared with an aDCSI score of 0) were 1.01 (1.00−1.14), 1.38 (1.35−1.42), 1.58 (1.54−1.63), and 2.23 (2.14−2.33), respectively. Conclusion: Patients with type 2 diabetes and sarcopenia had higher mortality than did those without sarcopenia.

Keywords: nonsarcopenia; prognostic factors; sarcopenia; survival; type 2 diabetes.

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Conflict of interest statement

The authors have no potential conflict of interest to declare.

Figures

**Figure 1**
Sensitivity analysis of sex, age group, and adapted Diabetes Complications Severity Index scores performed using the inverse probability of treatment weighting for all-cause death in patients with diabetes with and without sarcopenia. Abbreviations: aHR, adjusted hazard ratio; y, years old; aDCSI, adapted Diabetes Complications Severity Index; CI, confidence interval; ref., reference group. All covariates presented in Table 2 were adjusted.

**Figure 2**
Kaplan–Meier overall survival curves for patients with diabetes with and without sarcopenia.

See this image and copyright information in PMC

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Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score-Matched Diabetes Cohort Study

Affiliations

Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score-Matched Diabetes Cohort Study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources