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. 2022 Aug 1;11(15):4488.
doi: 10.3390/jcm11154488.

High Tg/HDL-Cholesterol Ratio Highlights a Higher Risk of Metabolic Syndrome in Children and Adolescents with Severe Obesity

Giorgio Radetti  1 , Graziano Grugni  2 , Fiorenzo Lupi  3 , Antonio Fanolla  4 , Diana Caroli  2 , Adele Bondesan  2 , Alessandro Sartorio  2
Affiliations

High Tg/HDL-Cholesterol Ratio Highlights a Higher Risk of Metabolic Syndrome in Children and Adolescents with Severe Obesity

Giorgio Radetti et al. J Clin Med. .

Abstract

Few data are currently available on the reliability of the different anthropometric, instrumental and biochemical indexes in recognizing the presence of metabolic syndrome (MetS) in children and adolescents with severe obesity. Therefore, the objective of our study was to find out the simplest and most accurate predictive index of MetS in this population at-risk. In 1065 children and adolescents (563 f, 502 m), aged 14.6 ± 2.1 years (range 10-17), with severe obesity [BMI-SDS 3.50 ± 0.36 (range 3.00-5.17)], the following indexes were evaluated: BMI, BMI-SDS, Tri-Ponderal Mass Index, Waist-to-Height ratio, TG/HDL-Cholesterol ratio, Cardiometabolic Index (CMI), and Visceral Adiposity Index (VAI). For each subject, all the components of MetS, defined according to the IDF criteria, were determined. Overall, the presence of MetS was found in 324 patients (30.4%), 167 males (33.3%) and 157 females (27.9%). According to the ROC analysis, three indexes (VAI, CMI and TG/HDL-Cholesterol ratio), performed significantly better than the other ones in identifying MetS, with no difference among them. In conclusion, the TG/HDL ratio, which just needs the evaluation of two simple biochemical parameters, offers the same accuracy as other more sophisticated indexes in recognizing MetS in children and adolescents with severe obesity, thus making it the best predictor to be easily used.

Keywords: adolescents; children; indexes; metabolic syndrome.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
ROC curve in boys. Abbreviations: VAI: Visceral Adiposity Index; WtHR: Waist-to-Height ratio; TMI: Tri-Ponderal Mass Index; TG/HDL: triglyceride to high density-lipoprotein cholesterol ratio; CMI: Cardiometabolic Index; BMI: Body Mass Index.
Figure 2
Figure 2
ROC curve in girls. Abbreviations: VAI: Visceral Adiposity Index; WtHR: Waist-to-Height ratio; TMI: Tri-Ponderal Mass Index; TG/HDL: triglyceride to high density-lipoprotein cholesterol ratio; CMI: Cardiometabolic Index; BMI: Body Mass Index.
Figure 3
Figure 3
Trend of TG/HDL cutoff for MetS, according to age and sex. The mean difference of the cut-off values calculated at all ages between sexes (p < 0.05). Abbreviation: TG/HDL: triglyceride to high density-lipoprotein cholesterol ratio.
See this image and copyright information in PMC

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