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Review
. 2022 Jul 31;27(15):4893.
doi: 10.3390/molecules27154893.

HIF in Gastric Cancer: Regulation and Therapeutic Target

Mengqing Li  1   2 , Guan Li  3 , Xiaodong Yang  1 , Weihua Yin  2 , Guoqing Lv  3 , Shubin Wang  1
Affiliations
Review

HIF in Gastric Cancer: Regulation and Therapeutic Target

Mengqing Li et al. Molecules. .

Abstract

HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer.

Keywords: HIF; gastric cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The mechanism of function of HIF1 under normoxia and hypoxia.
Figure 2
Figure 2
Treatments for advanced gastric cancer.
Figure 3
Figure 3
HIF could regulate the occurrence and development of gastric cancer.
Figure 4
Figure 4
HIF1α/miR-17-5p/PDCD4 axis contributes to the tumor growth of gastric cancer.
Figure 5
Figure 5
HIF1α-Induced LXRα contributes to the metastasis of gastric cancer cells.
See this image and copyright information in PMC

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