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. 1987 Apr 14;136(2):239-42.
doi: 10.1016/0014-2999(87)90717-5.

Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin

D J Stewart, T Münzel, E Bassenge

Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin

D J Stewart et al. Eur J Pharmacol. .

Abstract

In large arteries, acetylcholine-induced dilation is mediated by endothelium-derived relaxing factor (EDRF) and can be blocked by hemoglobin (Hb). However, the role of EDRF in the microcirculation is uncertain. Therefore, the effect of Hb on acetylcholine-induced dilation of resistance vessels was studied in isolated, constant-flow perfused rabbit hearts. Hb reversibly blocked the acetylcholine-induced lowering of perfusion pressure (control -27 +/- 3%; during Hb 0 +/- 4%) without inhibiting responses to other dilators, strongly suggesting that acetylcholine action in the microcirculation is mediated by EDRF.

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