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. 1987 Apr 14;136(2):247-50.
doi: 10.1016/0014-2999(87)90719-9.

Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea

D W Hay, R M Muccitelli, D L Horstemeyer, K A Wilson, D Raeburn

Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea

D W Hay et al. Eur J Pharmacol. .

Abstract

Using a novel preparation of guinea-pig trachea, direct evidence was obtained for the release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen. Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was positioned in close proximity to the tissue from which tension was recorded.

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