Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 22:13:955643.
doi: 10.3389/fgene.2022.955643. eCollection 2022.

Application of 3D printing individualized guide plates in percutaneous needle biopsy of acetabular tumors

Wen Wu  1 , Siyu Liu  2 , Lei Wang  1 , Bing Wu  2 , Lulu Zhao  2 , Wenbo Jiang  3 , Kerong Dai  1 , Yongqiang Hao  1 , Lingjie Fu  1 , Songtao Ai  2
Affiliations

Application of 3D printing individualized guide plates in percutaneous needle biopsy of acetabular tumors

Wen Wu et al. Front Genet. .

Abstract

Objective: The objective of the study was to investigate the effectiveness of applying the individualized guide plate which is based on digital image processing and 3D printing technology to percutaneous needle biopsy of periacetabular tumor. Methods: From July 2017 to August 2019, 11 patients (5 males and 6 females, aged 13-70 years, mean 42.3 years) with acetabular tumors diagnosed by needle biopsy in our hospital were enrolled in this retrospective study. Preoperative CT and MRI enhancement examination were performed routinely, and the DICOM data were collected and imported into Medraw Print software. According to the specific anatomical morphology of acetabula, this study adopted the reverse calculation and direct design to print the individualized puncture guide plate using 3D printing technology. The puncture point and sampling approaches were determined by the guide plate morphology and the "double guide-hole and slideable groove" design. First, we evaluated the fitness of the 3D guide plate to the local anatomical structure, its assisted-puncture accuracy was estimated by imaging examinations, and postoperative complications were recorded. The accuracy of the needle biopsy pathological result was estimated with reference to that of the tumor resection. Results: Our results showed that the 3D printing individualized guide plate matched the patients' pelvic skin well, the puncture approach was consistent with the preoperative design, and no significant anatomical injuries including vascular and neural complications occurred after surgery. Nine patients' (90%) biopsy results were consistent with their postoperative pathological results, and one patient gave up the tumor resection. Conclusion: Based on digital image processing and 3D printing technology, the individualized guide plate can be used to guide the needle biopsy of acetabular tumors which makes the operation simpler and more precise.

Keywords: 3D printing technology; acetabular tumors; image registration, and fusion; individualized guide plate; needle biopsy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Design concept of the individualized guide plate for 3D printing.
FIGURE 2
FIGURE 2
Operation procedure of the 3D printing individualized guide plate.
FIGURE 3
FIGURE 3
Clinical treatment of the 3D printing individualized guide plate. (A) Appearance of the 3D printing individualized guide plate. (B–D) Surgical procedures. (E) X-ray showed the bone tumor in the left acetabulum. (F) 3D model of the individualized guide plate. (G–H) Puncture location was confirmed by intraoperative X-ray fluoroscopy. (I) Tissue sample was obtained by needle biopsy. (J) Pathological section was obtained by needle biopsy (×100, HE staining). (K) Pathological section (×100, HE staining) after the tumor resection suggested giant cell tumor of bone, which was consistent with that of (J).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Chang C. Y., Huang A. J., Bredella M. A., Torriani M., Halpern E. F., Rosenthal D. I., et al. (2015). Percutaneous CT-guided needle biopsies of musculoskeletal tumors: A 5-year analysis of non-diagnostic biopsies. Skelet. Radiol. 44 (12), 1795–1803. 10.1007/s00256-015-2235-0 - DOI - PubMed
    1. Filippiadis D. K., Charalampopoulos G., Mazioti A., Keramida K., Kelekis A. (2018). Bone and soft-tissue biopsies: What you need to know. Semin. Interv. Radiol. 35 (4), 215–220. 10.1055/s-0038-1669467 - DOI - PMC - PubMed
    1. Guan W., Chen B., Zhang Y. (2017). Clinical application of 3D printing coplanar puncture template assisted CT guided percutaneous biopsy of primary lung small nodules[J]. Oncol. Prog. 15 (9), 1003–1007.
    1. Gupta S., Madoff D. C., Ahrar K., Morello F. A., Wallace M. J., Murthy R., et al. (2003). CT-guided needle biopsy of deep pelvic lesions by extraperitoneal approach through iliopsoas muscle. Cardiovasc. Interv. Radiol. 26 (6), 534–538. 10.1007/s00270-003-0035-8 - DOI - PubMed
    1. Gupta S., Nguyen H. L., Morello F. A., Jr, Ahrar K., Wallace M. J., Madoff D. C., et al. (2004). Various approaches for CT-guided percutaneous biopsy of deep pelvic lesions: Anatomic and technical considerations. Radiographics 24 (1), 175–189. 10.1148/rg.241035063 - DOI - PubMed

LinkOut - more resources