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. 2022 Jul 25:12:772102.
doi: 10.3389/fonc.2022.772102. eCollection 2022.

Effect of depression disorder on the efficacy and quality of life of first-line chemotherapy combined with immunotherapy in oncogene-driver negative NSCLC patients

Wen Li  1 , Ziran Bi  1 , Junxu Wu  2 , Xu Duan  1 , Lulian Pang  1 , Yanyan Jing  1 , Xiangxiang Yin  1 , Huaidong Cheng  1
Affiliations

Effect of depression disorder on the efficacy and quality of life of first-line chemotherapy combined with immunotherapy in oncogene-driver negative NSCLC patients

Wen Li et al. Front Oncol. .

Abstract

Objective: The current research was to assess the relevance between depression disorder and first-line chemotherapy combined with immunotherapy, quality of life in patients with oncogene-driver negative non-small cell cancer (NSCLC).

Methods: NSCLC patients (33 with depression disorder and 34 with no depression disorder) who was received first-line chemotherapy combined with immunotherapy performed Zung Self-rating Depression Scale (SDS) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30).

Results: The Progression-Free Survival (PFS) of depression disorder group survivors were lower than these of no depression disorder group survivors (HR, 0.352; 95% CI, 0.201-0.617; P<0.05). The statistical significant was revealed about the Objective Response Rate (ORR) and Disease Control Rate (DCR) in two groups (P<0.05). The quality of life scores of NSCLC patients in no depression disorder group was significantly higher after chemotherapy combined with immunotherapy, and manifested as 92.7 ± 28 vs. 76.3 ± 23.3 (t=8.317, P<0.05), and had a significant difference.

Conclusion: Depression disorder in oncogene-driver negative NSCLC patients influence the curative effect of chemotherapy combined with immunotherapy, and depression disorder was significantly negatively associated with quality of life following chemotherapy combined with immunotherapy.

Keywords: NCCLC; chemotherapy; depression disorder; first-line; immunotherapy; quality of life.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Research Flowchart. SDS, Self-Rating Depression Scale.
Figure 2
Figure 2
Correlation between depression disorder and chemotherapy combined with immunotherapy in patients with oncogene-driver negative NSCLC. PR, partial response; SD, stable disease; PD, progressive disease.
Figure 3
Figure 3
Relationship between depression disorder and quality of life after chemotherapy combined with immunotherapy.
Figure 4
Figure 4
Progression-free survival in patients with oncogene-driver negative non-small cell lung cancer receiving chemotherapy combined with immunotherapy.
See this image and copyright information in PMC

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