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Review
. 2022 Aug 2:2022:2049371.
doi: 10.1155/2022/2049371. eCollection 2022.

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Weili Xia  1 , Yong Xu  1 , Yuandong Gong  1 , Xiaojing Cheng  1 , Tiangui Yu  1 , Gongchang Yu  1   2
Affiliations
Review

Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Weili Xia et al. Oxid Med Cell Longev. .

Retraction in

Abstract

Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.

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Conflict of interest statement

The authors declare that they have no competing interests.

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