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Review
. 2022 Jul 25:9:971491.
doi: 10.3389/fcvm.2022.971491. eCollection 2022.

Forsythiasides: A review of the pharmacological effects

Hong-Xuan Yang  1 , Qiu-Ping Liu  1 , Yan-Xi Zhou  2   3 , Yu-Ying Chen  1 , Pei An  1 , Yi-Zhuo Xing  1 , Lei Zhang  4 , Min Jia  5 , Hong Zhang  1
Affiliations
Review

Forsythiasides: A review of the pharmacological effects

Hong-Xuan Yang et al. Front Cardiovasc Med. .

Abstract

Forsythiasides are a kind of phenylethanol glycosides existing in Forsythia suspensa (Thunb.) Vahl, which possesses extensive pharmacological activities. According to the different groups connected to the nucleus, forsythiasides can be divided into A-K. In recent years, numerous investigations have been carried out on forsythiasides A, B, C, D, E, and I, which have the effects of cardiovascular protection, anti-inflammation, anti-oxidation, neuroprotection, et al. Mechanistically, forsythiasides regulate toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor kappaB (NF-κB), nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and other signaling pathways, as well as the expression of related cytokines and kinases. Further exploration and development may unearth more treatment potential of forsythiasides and provide more evidence for their clinical applications. In summary, forsythiasides have high development and application value.

Keywords: Forsythia suspensa; anti-inflammation; anti-oxidation; cardiovascular protection; forsythiasides.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Structures of forsythiaside A (A) and forsythiaside B (B).
FIGURE 2
FIGURE 2
Mechanism of anti-inflammation and anti-oxidation by forsythiasides.
See this image and copyright information in PMC

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