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Review
. 2022 Jul 15;14(7):4391-4405.
eCollection 2022.

Role of matrix metalloproteinase in wound healing

Mimansa Kandhwal  1 , Tapan Behl  1 , Sukhbir Singh  1 , Neelam Sharma  1 , Sandeep Arora  1 , Saurabh Bhatia  2   3 , Ahmed Al-Harrasi  2 , Monika Sachdeva  4 , Simona Bungau  5
Affiliations
Review

Role of matrix metalloproteinase in wound healing

Mimansa Kandhwal et al. Am J Transl Res. .

Abstract

Matrix metalloproteinases (MMPs) are a group of endopeptidases that play a vital role in the restoration of damaged skin. Through mediating various cellular events such as angiogenesis and vasodilation, MMPs are very crucial for the mechanism of wound healing. These enzymes are endopeptidases that are reliant on zinc which are concealed through the extracellular matrix (ECM). MMPs have different targets in different phases of wound healing through which they are capable of promoting timely healing in the body. This review discusses all the possible role of MMPs and their inhibitors that are involved during every step of the wound healing process. This review highlights the latest advances in the respective field about the regulation and mediation of MMPs in human skin and how these studies can be applied to other branches of medical sciences as well. Published papers were searched via MEDLINE, PubMed and MDPI from the available peer reviewed journals. Research done in the past suggests that active MMPs are involved in the healing progression of the wounds or they have a positive effect towards healing of wounds. Present studies in the relative field will further enhance the knowledge about enzymes working along with their inhibitors. These studies will help in a way to resolve some of the parameters that are necessary for modulating them either positively or negatively.

Keywords: MMPs; TIMPs; chemokines; chronic wounds; extracellular matrix; inflammation; wound healing.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Diagrammatic representation of well-orchestrated events involved in the wound healing cascade.
Figure 2
Figure 2
Diagrammatic illustration of the events during the complex wound healing process and the role of specific MMPs during each well-orchestrated event.
Figure 3
Figure 3
Pictorial illustration of the dermis layer and the role of MMPs and their respective inhibitors in wound healing.
See this image and copyright information in PMC

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