Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 15;14(7):4918-4930.
eCollection 2022.

Global research hotspots and trends of the Notch signaling pathway in the field of cancer: a bibliometric study

Kunyang Lei  1 , Xu Wang  2 , Yifu Liu  1 , Ting Sun  1 , Wenjie Xie  1
Affiliations

Global research hotspots and trends of the Notch signaling pathway in the field of cancer: a bibliometric study

Kunyang Lei et al. Am J Transl Res. .

Abstract

Objectives: To analyze the development status, research hotspots, research frontiers and future development trends of the Notch signaling pathway in cancer through bibliometric analysis.

Methods: Publications related to the Notch signaling pathway in cancer were obtained from the Web of Science Core Collection (WoSCC), and information was extracted from the articles using Microsoft Excel 2020, CiteSpace V and VOSviewer software for visual analysis.

Results: The country and institution with the most publications are the USA and Harvard University, respectively. PLoS One is the most published journal, and Cancer Research is the most cocited journal. The author with the most published articles was L Miele, and the most cocited author was ZW Wang. The top 3 keywords were activation, differentiation and growth. Metastasis, epithelial-mesenchymal transition (EMT), invasion, target and resistance are the current research hotspots and frontiers in this field.

Conclusions: Research related to the Notch signaling pathway in cancer is currently booming, and the USA has made the greatest contribution to this field. At present, the research hotspots and research frontiers in this field mainly focus on the regulatory role of the Notch signaling pathway in tumor invasion and metastasis, the regulation of the Notch signaling pathway in tumor progression through EMT, and the participation of the Notch signaling pathway in the regulation of chemotherapy or immunotherapy resistance to tumors.

Keywords: Bibliometric; EMT; Notch; metastasis; resistance.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Flowchart of literature selection.
Figure 2
Figure 2
Annual number and growth trends of publications from 2001 to 2021.
Figure 3
Figure 3
(A) Number of publications per country per year; (B) Cooperation between countries/regions; and (C) cooperation between various institutions.
Figure 4
Figure 4
(A) Network map of active authors; and (B) network map of cocited authors.
Figure 5
Figure 5
(A) Network of cocited journals; and (B) dual-map overlay of journals.
Figure 6
Figure 6
(A) Network of cocited references; and (B) top 20 references with the strongest citation bursts.
Figure 7
Figure 7
(A) Clustering analysis of the keywords; and (B) trends of key word changes over time.
Figure 8
Figure 8
Top 20 keywords with the strongest citation bursts.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Hounjet J, Vooijs M. The role of intracellular trafficking of notch receptors in ligand-independent notch activation. Biomolecules. 2021;11:1369. - PMC - PubMed
    1. Shen W, Huang J, Wang Y. Biological significance of NOTCH signaling strength. Front Cell Dev Bio. 2021;9:652273. - PMC - PubMed
    1. McIntyre B, Asahara T, Alev C. Overview of basic mechanisms of notch signaling in development and disease. Adv Exp Med Biol. 2020;1227:9–27. - PubMed
    1. Misiorek J, Przybyszewska-Podstawka A, Kałafut J, Paziewska B, Rolle K, Rivero-Müller A, Nees M. Context matters: NOTCH signatures and pathway in cancer progression and metastasis. Cells. 2021;10:94. - PMC - PubMed
    1. Gragnani L, Lorini S, Marri S, Zignego A. Role of notch receptors in hematologic malignancies. Cells. 2020;10:16. - PMC - PubMed

LinkOut - more resources