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. 2022 Jul 15;14(7):5124-5131.
eCollection 2022.

Preliminary genome wide screening identifies new variants associated with coronary artery disease in Indian population

Keshavamurthy Ganapathy Bhat  1 , Vivek Singh Guleria  1 , Ratheesh Kumar J  1 , Garima Rastogi  2 , Varun Sharma  2 , Anuka Sharma  2
Affiliations

Preliminary genome wide screening identifies new variants associated with coronary artery disease in Indian population

Keshavamurthy Ganapathy Bhat et al. Am J Transl Res. .

Abstract

Aim: Coronary artery disease (CAD) is a major health problem in developed and developing nations. Development of CAD involves a complex interaction between genetics and lifestyle factors. Individuals with high-risk genetic predisposition along with poor lifestyle are more inclined to the development of CAD. Advancement in genotyping technologies and increase in genome wide studies has provided a platform to identify new risk factors associated with CAD and associated complexities.

Methodology: In this study we performed genome wide screening in 76 well-defined CAD cases and 77 control samples in Indian population. Interestingly, new variants are identified in three genes viz, VLDLR, IFITM2 and C2CD4C.

Results: The odds ratios observed for variant rs1869592 (VLDLR), rs1059091 (IFITMI) and rs7247159 (C2CD4C) were 2.6 (1.4-4.8 95% CI), 1.9 (95% CI 1.2-3.1) and 2.1 (1.2-3.7 95% CI), respectively with significant P value <0.01. These variants that are associated with pathogenesis of CAD were not previously reported in literature. Moreover, we anticipate that these variants will be further validated using a larger sample size.

Keywords: GWAS; Indian population; association; coronary artery disease.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Population attribution risk recognized by three associated variants in study population group.
Figure 2
Figure 2
Heat map of gene expression of the genes that were observed associated with CAD in studied population group.
Figure 3
Figure 3
Network analyses represent genetic interaction among identified genes associated with CAD.
See this image and copyright information in PMC

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