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. 2022 Jul 15;14(7):5116-5123.
eCollection 2022.

Therapeutic effect of Biyuan tongqiao granules combined with mometasone furoate nasal spray on clinical symptoms of children with allergic rhinitis

Zan Ding  1 , Nana Yang  1 , Xin Cui  1 , De Zhou  1
Affiliations

Therapeutic effect of Biyuan tongqiao granules combined with mometasone furoate nasal spray on clinical symptoms of children with allergic rhinitis

Zan Ding et al. Am J Transl Res. .

Abstract

Objective: To explore the clinical benefits of Biyuan Tongqiao granules (BTG) combined with mometasone furoate nasal spray (MFNS) on the symptoms of children with allergic rhinitis (AR).

Methods: Seventy-eight children with AR who visited the Pediatric Department of our hospital from May 2019 to May 2020 were selected and randomly divided into the BTG group (treated with BTG alone), MFNS group (treated with MFNS alone), and combined group (children with the combined use of BTG and MFNS), with 26 cases in each group. The nasal symptoms and oculonasal symptoms were evaluated and observed at baseline and 2 months after treatment.

Results: Children in the combination group had significantly lower total nasal symptom score (TNSS), total non-nasal symptom score (TNNSS) scores, and visual analogue scale (VAS) scores than those with BTG alone and MFNS alone (P<0.05). The overall response rate was 69.23% in children with BTG alone, 80.77% in children with MFNS alone, and 92.31% in children with the combined treatment.

Conclusion: BTG combined with MFNS can improve the symptoms of sneezing and nasal congestion, which is better than single drug treatment.

Keywords: Biyuan tongqiao granules; allergic rhinitis in children; mometasone furoate aqueous nasal spray.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of treatment efficacies. The overall response rate in MFNS group was higher than that in the BTG group, and the overall response rate in the combination group was significantly higher than that in BTG or MFNS group (P<0.05). * compared with BTG alone, # compared with MFNS alone. BTG, Biyuan Tongqiao granules; MFNS, mometasone furoate nasal spray.
Figure 2
Figure 2
Analysis of nasal symptoms. The total nasal symptom score (TNSS) and total non-nasal symptom score (TNNSS) of children in all three groups after treatment were significantly lower than those before treatment (P<0.05). The TNSS and TNNSS scores for children in the MFNS group and combination group were significantly lower than those in the BTG group (P<0.05), and the scores for children in the combination group were significantly lower than those in the MFNS group (P<0.05). & compared with before and after treatment, * compared with BTG alone, # compared with MFNS alone. BTG, Biyuan Tongqiao granules; MFNS, mometasone furoate nasal spray.
Figure 3
Figure 3
Improvement in oculonasal symptoms. Visual analogue scale (VAS) scores for children in the three groups after treatment were significantly lower than those before treatment (P<0.05). The VAS scores of children in the MFNS group and combination group were significantly lower than those in the BTG group (P<0.05), and the VAS scores of combination group were significantly lower than those with MFNS group (P<0.05). & compared with before and after treatment, * compared with BTG alone, # compared with MFNS alone. BTG, Biyuan Tongqiao granules; MFNS, mometasone furoate nasal spray.
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