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Review
. 2022 Aug 2:2022:2665903.
doi: 10.1155/2022/2665903. eCollection 2022.

Antineoplastic Effects of Ankaferd Hemostat

Umit Yavuz Malkan  1 , Ibrahim Celalettin Haznedaroglu  1
Affiliations
Review

Antineoplastic Effects of Ankaferd Hemostat

Umit Yavuz Malkan et al. Biomed Res Int. .

Abstract

Materials and methods: Up to June 2022, literature searches were performed using the internet search engines Medline, Google Scholar, and Embase: Ankaferd. PRISMA flow diagram described the Ankaferd search.

Results: ABS have important effects in several cellular processes, like control of the cell cycle, apoptosis, angiogenesis, signal transduction, inflammation, immunologic, and metabolic mechanisms. The molecular basis of antineoplastic roles of ABS depends on its proteomics, metabolomics, and transcriptomics features. ABS has antineoplastic effects on solid tumors like colon, bladder, breast, and osteosarcoma cancer cells. Also, ABS effects renal tubular apoptosis and has antitumoral roles on malign melanoma cells. ABS inhibits hematological tumors like myeloma and lymphoid cells. ABS induces apoptosis in retinal cells and has inhibitory effects on mesenchymal stem cells. It has an antiproliferative role on gastrointestinal tumors like hepatocellular carcinoma cells. Moreover, ABS has a treatment supportive role in cancer since it can prevent oxidative DNA damage and decrease the intestinal damage in necrotizing enterocolitis. Furthermore, it has chemopreventive and hepatoprotective features and can be used for prophylaxis and treatment of oral mucositis.

Conclusion: ABS alters cell metabolism and cell cycle. ABS has antineoplastic role on cancer cells. The expanding context of ABS compromises anti-infective, antineoplastic, and wound healing features. ABS may also be used for the palliative, adjuvant, neoadjuvant, or supportive use by interventional radiology procedures for the treatment of solid tumors. Future controlled studies are necessary to clarify the pleiotropic role of ABS like antineoplastic, antithrombotic, anti-inflammatory, anti-infective, antifungal, and antioxidative effects.

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Conflict of interest statement

The authors declare that there is no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
The PRISMA flow diagram for the Ankaferd search.
Figure 2
Figure 2
The scheme of downregulated (a) and upregulated (b) proteins after Ankaferd hemostat (ABS) given on the human colon cancer cell line, CACO-2 (reproduced with the open access policy of the Journal; Bio Med Res (https://www.hindawi.com/journals/bmri/2019/5268031/fig 4/).
Figure 3
Figure 3
The classification of upregulated proteins in cellular component (a), in organelles (b), and in cellular processes (c) after Ankaferd hemostat (ABS) given on the human colon cancer cell line, CACO-2 (reproduced with the open access policy of the Journal; Bio Med Res (https://www.hindawi.com/journals/bmri/2019/5268031/fig 3/).
Figure 4
Figure 4
The inhibitory effect of Ankaferd Hemostat (ABS) on the Saos-2 cells. (a) The control group without ABS (10× magnification). (b) 10 μL ABS given Saos-2 cells (10× magnification) at the seventeenth day.
Figure 5
Figure 5
The inhibitory effect of Ankaferd Hemostat (ABS) on the CaCo-2 cells. (a) The control group without ABS (10× magnification). (b) 10 μL ABS given CaCo-2 cells (10× magnification) at the sixteenth day.
Figure 6
Figure 6
In vitro proliferation of the MSCs was negatively affected by Ankaferd Hemostat (ABS) due to intense aggregation. (a) The control group without ABS (10× magnification). (b) 10 μL ABS given mesenchymal stem cells (10× magnification) at the fourteenth day.
See this image and copyright information in PMC

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