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. 2022 Jul 25:10:946186.
doi: 10.3389/fpubh.2022.946186. eCollection 2022.

Perinatal outcomes among twin pregnancies with gestational diabetes mellitus: A nine-year retrospective cohort study

Dongxin Lin  1   2 , Dazhi Fan  1   2 , Pengsheng Li  1   2 , Gengdong Chen  1   2 , Jiaming Rao  1   2 , Zixing Zhou  1   2 , Huishan Zhang  1   2 , Xin Luo  1   2 , Huiting Ma  1   2 , Jingping Feng  2 , Demei Lu  2 , Lijuan Wang  2 , Shiyan Lan  2 , Caihong Luo  2 , Xiaoling Guo  1   2 , Zhengping Liu  1   2
Affiliations

Perinatal outcomes among twin pregnancies with gestational diabetes mellitus: A nine-year retrospective cohort study

Dongxin Lin et al. Front Public Health. .

Abstract

Objective: To compare the outcomes between gestational diabetes mellitus (GDM) vs. non-GDM twin gestations.

Methods: A retrospective cohort study of 2,151 twin pregnancies was performed in a tertiary hospital in Foshan, China, 2012-2020. Pregnancy and neonatal outcomes were compared between women with vs. without GDM using 1:1 propensity score matching (PSM) and multivariable logistic models. For neonatal outcomes, generalized estimating equation (GEE) approach was used to address the intertwin correlation.

Results: Of the 2,151 participants, 472 women (21.9%) were diagnosed with GDM. Women with GDM were older and more likely to be overweight or obese, and more likely have chronic hypertension, assisted pregnancies and dichorionic twins. In the PSM cohort of 942 pregnancies, there was no statistical difference when comparing GDM twin pregnancies and non-GDM in any of the perinatal outcomes, especially in terms of preterm birth (PTB) <37 weeks (P = 0.715), large for gestational age (LGA) (P = 0.521) and neonatal respiratory distress (NRDS) (P = 0.206). In the entire cohort, no significant adjusted ORs for these outcomes were obtained from logistic regression models adjusted for confounders (aOR for PTB < 37 weeks: 1.25, 95% CI: 0.98-1.58; aOR for LGA: 1.26, 95% CI: 0.88-1.82; and aOR for NRDS, 1.05, 95% CI: 0.68-1.64).

Conclusion: Twin pregnancies with GDM and adequate prenatal care have comparable perinatal outcomes to those without.

Keywords: gestational diabetes mellitus; neonatal outcome; perinatal outcome; pregnancy outcome; twin pregnancy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Selection of eligible participants.
See this image and copyright information in PMC

References

    1. Griffin ME, Coffey M, Johnson H, Scanlon P, Foley M, Stronge J, et al. . Universal vs. risk factor-based screening for gestational diabetes mellitus: detection rates, gestation at diagnosis and outcome. Diabetic Med J Br Diabetic Assoc. (2000) 17:26–32. 10.1046/j.1464-5491.2000.00214.x - DOI - PubMed
    1. Ferrara A. Increasing prevalence of gestational diabetes mellitus: a public health perspective. Diabetes Care. (2007) 30(Suppl 2):S141–6. 10.2337/dc07-s206 - DOI - PubMed
    1. Saeedi M, Cao Y, Fadl H, Gustafson H, Simmons D. Increasing prevalence of gestational diabetes mellitus when implementing the Iadpsg criteria: a systematic review and meta-analysis. Diabetes Res Clin Pract. (2021) 172:108642. 10.1016/j.diabres.2020.108642 - DOI - PubMed
    1. Ramezani Tehrani F, Naz MSG, Yarandi RB, Behboudi-Gandevani S. The impact of diagnostic criteria for gestational diabetes mellitus on adverse maternal outcomes: a systematic review and meta-analysis. J Clin Med. (2021) 10:666. 10.3390/jcm10040666 - DOI - PMC - PubMed
    1. Hosseini E, Janghorbani M. Systematic review and meta-analysis of diagnosing gestational diabetes mellitus with one-step or two-step approaches and associations with adverse pregnancy outcomes. Int J Gynaecol Obstet. (2018) 143:137–44. 10.1002/ijgo.12644 - DOI - PubMed