Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jul 9;14(7):e26690.
doi: 10.7759/cureus.26690. eCollection 2022 Jul.

Chyluria Associated With Nephrotic-Range Proteinuria

Amninder Kaur  1 , Sharon Kandari  1 , Sandeep Saini  1 , Dipesh K Dhoot  1 , Ashwani Kandari  2
Affiliations
Case Reports

Chyluria Associated With Nephrotic-Range Proteinuria

Amninder Kaur et al. Cureus. .

Abstract

Chyluria is the presence of chyle in the urine and is associated with some degree of proteinuria. We report two patients with chyluria who presented with milky urine, weight loss, and edema and were found to have nephrotic-range proteinuria. Although filarial antigen was detected in only one of the patients, flexible cystoscopy could demonstrate chyle efflux from the left ureter in first patient and from both the ureters in the second patient. Both patients received endoscopic sclerotherapy with 0.2% povidone-iodine, which resulted in the clearance of milky urine in three to five days and complete resolution of nephrotic-range proteinuria on follow-up. They remained symptom-free until the six-month follow-up. We deferred renal biopsy in both patients, as proteinuria was confirmed to be non-glomerular in origin.

Keywords: chyluria; filariasis; nephrotic syndrome; proteinuria; renal biopsy.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Milky urine (Case 1)
Figure 2
Figure 2. Urine on day 5 of sclerotherapy - Case 1
Figure 3
Figure 3. Cystoscopy demonstrating chyluria - Case 1
Figure 4
Figure 4. Milky urine - Case 2
Figure 5
Figure 5. Urine on day 3 of sclerotherapy - Case 2
See this image and copyright information in PMC

References

    1. Chyluria: a scourge of our region. Sinha RK, Ranjan N, Singh N, Amit K. https://casereports.bmj.com/content/2015/bcr-2014-209188 BMJ Case Rep. 2015;6:2014209188. - PMC - PubMed
    1. Analysis of case series of milky urine: a single center and departmental clinical experience with emphasis on management perspectives: a prospective observational study. Sunder S, Jayaraman R, Mahapatra HS, et al. https://pubmed.ncbi.nlm.nih.gov/25371613/ Urol Ann. 2014;6:340–345. - PMC - PubMed
    1. Chyluria associated with nephrotic-range proteinuria: pathophysiology, clinical picture and therapeutic options. Graziani G, Cucchiari D, Verdesca S, Balzarini L, Montanelli A, Ponticelli C. Nephron Clin Pract. 2011;119:0–53. - PubMed
    1. Chyluria - a review of the literature. Diamond E, Schapira HE. Urology. 1985;26:427–431. - PubMed
    1. Chyluria presenting as milky urine and nephrotic-range proteinuria. Cheng JT, Mohan S, Nasr SH, D'Agati VD. Kidney Int. 2006;70:1518–1522. - PubMed

Publication types

LinkOut - more resources