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. 2022;9(2):452-457.
Epub 2022 Jun 29.

Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders

Joseph Cichon  1 , Renyu Liu  1 , Hoang V Le  2
Affiliations

Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders

Joseph Cichon et al. Transl Perioper Pain Med. 2022.
No abstract available

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Conflict of interest statement

Conflicts of Interest The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:
Chemical structures of salvinorin A and some well-known analogues of salvinorin A. Herkinorin, PR-38, salvindolin, compound 1, and compound 2 (now known as salvidenin) are dual KOR/MOR agonists. RB-64 is a G-protein-biased KOR agonist that forms a covalent bond with KOR. β-Tetrahydropyran salvinorin B is a long-acting KOR agonist. 16-Ethynyl salvinorin A is a nonbiased KOR agonist. 16-Bromo salvinorin A is a G-protein-biased KOR agonist. 1α-Hydroxysalvinorin A is a KOR antagonist. KOR, kappa opioid receptor. MOR, mu opioid receptor.
Figure 2:
Figure 2:
Schematic showing the potential of salvinorin A in modulating neuronal activity and plasticity in the brain. Certain disease states could drive hyperexcitity in distinct circuits. Delivery of salvinorin A and KOR activation can rapidly decrease neuronal activity and synaptic plasticity. These rapid and sustained effects might reshape the connectivity and patterns of neuronal activity towards normal brain function. KOR, kappa opioid receptor. K, potassium. Ca, calcium. cAMP, cyclic adenosine monophosphate. PKA, protein kinase A.
See this image and copyright information in PMC

References

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