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Review
. 2022 Jul 25:9:965924.
doi: 10.3389/fmolb.2022.965924. eCollection 2022.

The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer

Lulu Zhang  1   2 , Yi Lu  1 , Xiaoli Ma  1   2 , Yuanxin Xing  1   2 , Jinbo Sun  3 , Yanfei Jia  1   2
Affiliations
Review

The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer

Lulu Zhang et al. Front Mol Biosci. .

Abstract

Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and increasing shreds of evidence demonstrate that G-quadruplexes have been associated with some important cellular events. Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigated to discover new effective anticancer drugs. Multiple modulations have been discovered between the secondary structure G-quadruplex and p53, probably further influencing the ferroptosis in cancer. G-quadruplex binds to ferric iron-related structures directly and may affect the p53 pathways as well as ferroptosis in cancer. In addition, G-quadruplex also interacts with p53 indirectly, including iron-sulfur cluster metabolism, telomere homeostasis, lipid peroxidation, and glycolysis. In this review, we summarized the latent interplay between G-quadruplex and p53 which focused mainly on ferroptosis in cancer to provide the potential understanding and encourage future studies.

Keywords: G-quadruplex; biological activities; cancer; ferroptosis; p53.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Regulation of ferroptosis by p53. Various proteins involved in iron metabolism and lipid peroxidation are modulated by p53.
FIGURE 2
FIGURE 2
Schematic diagram of the regulation network of G-quadruplex and p53 in ferroptosis (Created with BioRender.com).
See this image and copyright information in PMC

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