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Review
. 2022 Oct;237(10):3752-3767.
doi: 10.1002/jcp.30846. Epub 2022 Aug 12.

The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancer

Nasim Ebrahimi  1 , Jamileh Saremi  2 , Masoud Ghanaatian  3 , Elnaz Yazdani  4   5 , Samaneh Adelian  6 , Sahar Samsami  7 , Neda Moradi  8 , Nadi Rostami Ravari  9 , Amirhossein Ahmadi  10 , Michael R Hamblin  11 , Amir Reza Aref  12   13
Affiliations
Review

The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancer

Nasim Ebrahimi et al. J Cell Physiol. 2022 Oct.

Abstract

Cancer cells must overcome a variety of external and internal stresses to survive and proliferate. These unfavorable conditions include the accumulation of mutations, nutrient deficiency, oxidative stress, and hypoxia. These stresses can cause aggregation of misfolded proteins inside the endoplasmic reticulum. Under these conditions, the cell undergoes endoplasmic reticulum stress (ER-stress), and consequently initiates the unfolded protein response (UPR). Activation of the UPR triggers transcription factors and regulatory factors, including long noncoding RNAs (lncRNAs), which control the gene expression profile to maintain cellular stability and hemostasis. Recent investigations have shown that cancer cells can ensure their survival under adverse conditions by the UPR affecting the expression of lncRNAs. Therefore, understanding the relationship between lncRNA expression and ER stress could open new avenues, and suggest potential therapies to treat various types of cancer.

Keywords: ER stress; cell survival; long noncoding RNAs; signaling pathways; unfolded protein response (UPR).

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