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Review
. 2023 Jan;111(1):220-233.
doi: 10.1002/jbm.b.35146. Epub 2022 Aug 12.

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Matheus Morais Saraiva  1 , Matheus da Silva Campelo  1 , João Francisco Câmara Neto  1 , Ana Beatriz Nogueira Lima  1 , George de Almeida Silva  1 , Andre Tavares de Freitas Figueredo Dias  1 , Nágila Maria Pontes Silva Ricardo  1 , David L Kaplan  2 , Maria Elenir Nobre Pinho Ribeiro  1
Affiliations
Review

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Matheus Morais Saraiva et al. J Biomed Mater Res B Appl Biomater. 2023 Jan.

Abstract

The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

Keywords: biomaterial; biopolymer; polymer blend; skin; wound dressing.

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