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. 2022 Aug 12;101(32):e30025.
doi: 10.1097/MD.0000000000030025.

Fibroscan® and Shear Wave correlated well in hepatic fibrosis evaluation of patients with chronic liver diseases "in real life situation"

Honoré Tegwendé Zougmoré  1   2 , Jean François David Cadranel  1 , Gildas Fantognon  1 , Badia Azzi  3 , Ryad Smadhi  1 , Jean René Ngele Efole  1 , Samir Mrabti  1 , Ratmony Heng  1 , Marie Adrienne Ntsama  1 , Mourad Medmoun  1 , Firouzeh Kazerouni  3 , Tristan Le Magoarou  4
Affiliations

Fibroscan® and Shear Wave correlated well in hepatic fibrosis evaluation of patients with chronic liver diseases "in real life situation"

Honoré Tegwendé Zougmoré et al. Medicine (Baltimore). .

Abstract

Background: A new noninvasive medical device based on ultrasound elastography such as the Shear Wave Elastography (SWE) was designed in order to measure the liver hardness. The purpose of this work was to evaluate the correlation of the results of the liver elasticity measurements obtained by Fibroscan® (FS) and SWE for patients with chronic liver diseases.

Methods: Between January and October 2017, the patients who were followed during this period of time underwent noninvasive assessments of liver fibrosis by SWE in the intercostal spaces during abdominal ultrasound procedures and/or FS. The correlation between FS and SWE was estimated and tested at a 0.05 significance level.

Results: Four hundred and seventy-six patients were included in this study. The main etiologies of chronic liver disease were non alcoholic fatty disease (NAFLD), chronic viral hepatitis B (HBV) and chronic viral hepatitis C (HCV). All patients underwent a SWE and 167 among them underwent a FS procedure. The patients who were followed revealed a median FS measurement of 5.80 kpa (Q25 = 4.90 kPa; Q75 = 8 kPa) and a median SWE measurement of 7.00 kPa (Q25 = 6.10 kPa; Q75 = 8.10 kPa). We could observe a significant correlation between the FS and SWE measurements (0.49; P = .001) in the total cohort. The average absolute difference between the measurements of these 2 methods was of 2.54 kPa (sd = 3.39). There was no significant correlation for patients with NAFLD no matter whether they presented with signs of suspected non alcoholic steatohepatitis (NASH) or not (R = 0.20; P = .108). All patients intending to perform the examination were able to undergo the SWE, allowing 33.3% of the patients who failed the FS to have a noninvasive evaluation of their fibrosis.

Conclusion: The SWE technique proved to be as efficient as the FS one for the evaluation of the liver fibrosis in real life situation.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow chart of included patients.
Figure 2.
Figure 2.
correlation of FS and SWE measurement values in the total cohort.
Figure 3.
Figure 3.
Blant and Altman analysis of FS and SWE methods.
Figure 4.
Figure 4.
Correlation median LSM by FS and SWE in chronic HBV patients.
Figure 5.
Figure 5.
Correlation median LSM by FS and SWE in chronic HCV patients.
Figure 6.
Figure 6.
Correlation median LSM by FS and SWE in NAFLD patients.
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