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. 1987;33(3):214-22.
doi: 10.1111/j.1432-0436.1987.tb01560.x.

Morphological development of the mouse gonad in tda-1 XY sex reversal

C M Nagamine, T Taketo, G C Koo

Morphological development of the mouse gonad in tda-1 XY sex reversal

C M Nagamine et al. Differentiation. 1987.

Abstract

tda-1 XY sex reversal occurs when the Y chromosome of at least some populations of wild Mus musculus domesticus is placed on the C57BL/6J genomic background. Gross anatomical observations have previously revealed morphological similarities among fetal ovotestes of tda-1 and Tas-inherited XY sex reversals and BALB/cWt mosaic hermaphrodites. We studied the histology of tda-1 XY sex-reversed gonads, ranging in age from day 14 of gestation to adult. The obtained data revealed additional similarities with ovotestes of BALB/cWt mosaic hermaphrodites as well as with ovotestes of hermaphrodites found in XXSxr and XX/XY chimeras. It is proposed that ovotestes occurring in these various hermaphroditic conditions may be formed through a common pathway.

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