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Comment
. 2022 Aug 12;7(1):281.
doi: 10.1038/s41392-022-01114-8.

Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD)

Benedetto Daniele Giaimo  1 , Tilman Borggrefe  2
Affiliations
Comment

Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD)

Benedetto Daniele Giaimo et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic summary of the main findings of Zuin et al. a Gene expression depends on the enhancer-promoter distance. b Gene expression depends on contact probability by following a nonlinear relationship. c Enhancer strength determines its sensitivity to CTCF-mediated insulation
See this image and copyright information in PMC

Comment on

  • Nonlinear control of transcription through enhancer-promoter interactions.
    Zuin J, Roth G, Zhan Y, Cramard J, Redolfi J, Piskadlo E, Mach P, Kryzhanovska M, Tihanyi G, Kohler H, Eder M, Leemans C, van Steensel B, Meister P, Smallwood S, Giorgetti L. Zuin J, et al. Nature. 2022 Apr;604(7906):571-577. doi: 10.1038/s41586-022-04570-y. Epub 2022 Apr 13. Nature. 2022. PMID: 35418676 Free PMC article.

References

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    1. Giaimo BD, Friedrich T, Borggrefe T. A comprehensive toolbox to analyze enhancer-promoter functions. Methods Mol. Biol. 2021;2351:3–22. doi: 10.1007/978-1-0716-1597-3_1. - DOI - PubMed

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