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Comment
. 2022 Aug 12;7(1):282.
doi: 10.1038/s41392-022-01122-8.

Time's up: mutation rate and lifespan

Anjali Cremer  1   2   3 , Wesley T Abplanalp #  4   5   6   7 , Michael A Rieger #  8   9   10   11
Affiliations
Comment

Time's up: mutation rate and lifespan

Anjali Cremer et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mutation rate is inversely correlated with lifespan. Cagan et al. demonstrate by comparative whole-genome sequencing of clonal colon crypts that the mutational rate of somatic mutations (tachometer) is inversely correlated with the lifespan (hourglass) in mammals across 16 different species. However, the mutation burden at the end of life is highly similar among these species. This observation is largely independent from the respective body mass. The figure was generated with BioRender
See this image and copyright information in PMC

Comment on

  • Somatic mutation rates scale with lifespan across mammals.
    Cagan A, Baez-Ortega A, Brzozowska N, Abascal F, Coorens THH, Sanders MA, Lawson ARJ, Harvey LMR, Bhosle S, Jones D, Alcantara RE, Butler TM, Hooks Y, Roberts K, Anderson E, Lunn S, Flach E, Spiro S, Januszczak I, Wrigglesworth E, Jenkins H, Dallas T, Masters N, Perkins MW, Deaville R, Druce M, Bogeska R, Milsom MD, Neumann B, Gorman F, Constantino-Casas F, Peachey L, Bochynska D, Smith ESJ, Gerstung M, Campbell PJ, Murchison EP, Stratton MR, Martincorena I. Cagan A, et al. Nature. 2022 Apr;604(7906):517-524. doi: 10.1038/s41586-022-04618-z. Epub 2022 Apr 13. Nature. 2022. PMID: 35418684 Free PMC article.

References

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