Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Aug 12;7(1):280.
doi: 10.1038/s41392-022-01101-z.

Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation

Yu Chen #  1 , Jingchun Wang #  2 , Yongsheng Li  3
Affiliations
Comment

Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation

Yu Chen et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests. Yongsheng Li is the editorial board member of Signal Transduction and Targeted Therapy, but he has not been involved in the process of the manuscript handling.

Figures

Fig. 1
Fig. 1
MPC regulates memory CD8+ T cells differentiation and anti-tumor effect in adoptive cell therapy and tumor microenvironment. a In adoptive cell therapy, MPC deletion blocks pyruvate metabolism in CAR T cells, which facilitates the oxidation of fatty acids and glutamine in TCA. The increased acetyl-CoA enhances histone acetylation and chromatin accessibility of transcription factor RUNX1, which up-regulates pro-memory genes to promote the development of CD8+ memory T cells (Tmem), resulting in increased persistence and anti-tumor effect of CAR T cells. b In nutrient-limited TME, CD8+ T cells rely on lactate oxidation. MPC deficiency blunts pyruvate utilization and causes mTOR inactivation and H3K27 methylation, and impairs the anti-tumor function of CD8+ effector T cells (Teff)
See this image and copyright information in PMC

Comment on

References

    1. Wenes M, et al. The mitochondrial pyruvate carrier regulates memory T cell differentiation and anti-tumor function. Cell Metab. 2022;34:731–746.e9. doi: 10.1016/j.cmet.2022.03.013. - DOI - PMC - PubMed
    1. Ma EH, et al. Metabolic profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8+ T cells. Immunity. 2019;51:856–870.e5. doi: 10.1016/j.immuni.2019.09.003. - DOI - PubMed
    1. Ramstead AG, et al. Mitochondrial pyruvate carrier 1 promotes peripheral t cell homeostasis through metabolic regulation of thymic development. Cell Rep. 2020;30:2889–2899.e6. doi: 10.1016/j.celrep.2020.02.042. - DOI - PMC - PubMed
    1. Gray SM, et al. Polycomb repressive complex 2-mediated chromatin repression guides effector CD8+ T cell terminal differentiation and loss of multipotency. Immunity. 2017;46:596–608. doi: 10.1016/j.immuni.2017.03.012. - DOI - PMC - PubMed
    1. Chan JD, et al. Cellular networks controlling T cell persistence in adoptive cell therapy. Nat. Rev. Immunol. 2021;21:769–784. doi: 10.1038/s41577-021-00539-6. - DOI - PubMed

Publication types

MeSH terms

Substances