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. 2022 Nov;52(11):1343-1346.
doi: 10.1111/cea.14214. Epub 2022 Aug 23.

Clinical and immunological data from chronic urticaria onset after mRNA SARS-CoV-2 vaccines

Eva Pescosolido  1 , Yannick D Muller  2 , Marina Sabaté-Brescó  3 , Marta Ferrer  3 , Daniel Yerly  4 , Jean-Christoph Caubet  5 , Jean-Pierre Lantin  6 , Camillo Ribi  2 , Marcel M Bergmann  1   5   7
Affiliations

Clinical and immunological data from chronic urticaria onset after mRNA SARS-CoV-2 vaccines

Eva Pescosolido et al. Clin Exp Allergy. 2022 Nov.
No abstract available

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Conflict of interest statement

All the authors have no conflicts of interest to declare. All co‐authors have seen and agreed with the contents of the manuscript. There is no financial interest to report.

Figures

FIGURE 1
FIGURE 1
Result of basophil activation test to BNT 162b2, mRNA‐1273, Polysorbate‐80, TRIS, PEG‐2000 in 6 patients (patients 3, 5, 14, 15, 20, 22, 24). Hundred microliters of peripheral blood per test was incubated with or without IL‐3 (1 ng/ml) with different concentration of vaccines (1%, 0.1%, 0.01%) or Polysorbate‐80 (20, 10 and, 2 μg/ml), or TRIS (100, 10 or 1 μg/ml) or PEG‐2000 (50, 10, 2) for 30 min at 37°C, along with anti‐CCR3 PE and anti‐CD63 FITC, anti‐CD203 APC antibodies (Biolegend). Control conditions included a medium‐only negative control, a positive control, involving the crosslinking of the high‐affinity Fc epsilon receptor (anti‐FcERIIgE, Beckmann‐Coulter). Flow cytometry data were collected on NovoCyte flow cytometer (Agilent). After stimulation and staining, basophiles (gated by CCR3+ expression) were analysed for their degranulation (CD63) in the presence of IL‐3 (A), and for their degranulation (CD63, B) and activation (CD203c, C) in the absence of IL‐3. The percentage of event positive for the corresponding marker in CCR3+ gated events is presented for each tested patient. CCR3, C‐C chemokine receptor type 3; CD, cluster of differentiate; IL, interleukin; PEG, polyethylene glycol; TRIS, tromethamine.
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References

    1. Reports of suspected adverse reactions to COVID‐19 vaccines in Switzerland – update. Accessed November 26, 2021. https://www.swissmedic.ch/swissmedic/en/home/news/coronavirus‐covid‐19/c...
    1. Gentinetta T, Pecaric‐Petkovic T, Wan D, et al. Individual IL‐3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol. 2011;128(6):1227‐1234.e5. - PubMed
    1. Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta‐analysis. Allergy. 2020;75(2):423‐432. - PubMed
    1. Magen E, Shalom G, Waitman DA, Kahan NR. Chronic spontaneous urticaria following vaccination. Int J Adv Res. 2018;6(2):1434‐1439.
    1. Thomas J, Thomas G, Chatim A, Shukla P, Mardiney M. Chronic spontaneous urticaria after COVID‐19 vaccine. Cureus. 2021;13(9):e18102. - PMC - PubMed

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