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Comment
. 2022 Aug 12;3(8):521-522.
doi: 10.1016/j.medj.2022.07.004.

Pediatric precision oncology-Time for clinical prime time

Stefan M Pfister  1 , Olaf Witt  2 , David T W Jones  3
Affiliations
Free article
Comment

Pediatric precision oncology-Time for clinical prime time

Stefan M Pfister et al. Med. .
Free article

Abstract

Recent prospective molecular tumor-profiling studies in pediatric cancer patients across a variety of different healthcare systems have highlighted both the feasibility and clinical utility of this approach. The current study by Church and colleagues in Nature Medicine1 has further substantiated this and laid the groundwork for a systematic collaborative approach to pediatric precision oncology in the US.

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Conflict of interest statement

Declaration of interests S.M.P. receives grant support in the framework of an IMI-2 funded project from Eli-Lilly, Bayer, Roche, Pfizer, PharmaMar, Astra Zeneca, Amgen, Servier, Sanofi, and JnJ. S.M.P. holds a patent on a DNA-methylation-based method for classifying tumor species of the brain (EP3067432A1).

Comment on

  • Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.
    Church AJ, Corson LB, Kao PC, Imamovic-Tuco A, Reidy D, Doan D, Kang W, Pinto N, Maese L, Laetsch TW, Kim A, Colace SI, Macy ME, Applebaum MA, Bagatell R, Sabnis AJ, Weiser DA, Glade-Bender JL, Homans AC, Hipps J, Harris H, Manning D, Al-Ibraheemi A, Li Y, Gupta H, Cherniack AD, Lo YC, Strand GR, Lee LA, Pinches RS, Lazo De La Vega L, Harden MV, Lennon NJ, Choi S, Comeau H, Harris MH, Forrest SJ, Clinton CM, Crompton BD, Kamihara J, MacConaill LE, Volchenboum SL, Lindeman NI, Van Allen E, DuBois SG, London WB, Janeway KA. Church AJ, et al. Nat Med. 2022 Aug;28(8):1581-1589. doi: 10.1038/s41591-022-01856-6. Epub 2022 Jun 23. Nat Med. 2022. PMID: 35739269 Free PMC article.

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