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Comment
. 2022 Sep;43(9):687-689.
doi: 10.1016/j.it.2022.07.007. Epub 2022 Aug 10.

Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment

Kathryn Waller  1 , Charlotte L Scott  2
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Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment

Kathryn Waller et al. Trends Immunol. 2022 Sep.

Abstract

Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and reprogramming of the cells toward a cDC2-like phenotype.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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