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Comment
. 2022 Aug 13;7(1):284.
doi: 10.1038/s41392-022-01117-5.

Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis

Affiliations
Comment

Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis

Fengwu Chen et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests

Figures

Fig. 1
Fig. 1
Gut Brain Axis: It is a system composed of the brain and the gut in the body. The brain and the gut work together to regulate the immune responses, enteroendocrine, liver and gallbladder metabolism, neuronal innervation, microbial metabolite signaling (Left). Gut microbes affect feeding behavior by modulating brain function: the microbiota plays an important role in Nod2 ligand production and appetite regulation through Nod2-expressing hypothalamic neurons. The brain can assess food intake and regulation body temperature by sensing changes of gut microbes (Right)

Comment on

  • Bacterial sensing via neuronal Nod2 regulates appetite and body temperature.
    Gabanyi I, Lepousez G, Wheeler R, Vieites-Prado A, Nissant A, Chevalier G, Wagner S, Moigneu C, Dulauroy S, Hicham S, Polomack B, Verny F, Rosenstiel P, Renier N, Boneca IG, Eberl G, Lledo PM. Gabanyi I, et al. Science. 2022 Apr 15;376(6590):eabj3986. doi: 10.1126/science.abj3986. Epub 2022 Apr 15. Science. 2022. PMID: 35420957

References

    1. Gabanyi I, et al. Bacterial sensing via neuronal Nod2 regulates appetite and body temperature. Science. 2022;376:eabj3986. doi: 10.1126/science.abj3986. - DOI - PubMed
    1. Cryan JF, et al. The Microbiota-Gut-Brain Axis. Physiol. Rev. 2019;99:1877–2013. doi: 10.1152/physrev.00018.2018. - DOI - PubMed
    1. Morais LH, Schreiber HLT, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat. Rev. Microbiol. 2021;19:241–255. doi: 10.1038/s41579-020-00460-0. - DOI - PubMed
    1. Yu KB, Hsiao EY. Roles for the gut microbiota in regulating neuronal feeding circuits. J. Clin. Invest. 2021;131:e143772. doi: 10.1172/JCI143772. - DOI - PMC - PubMed
    1. Hou K, et al. Microbiota in health and diseases. Signal Transduct. Target. Ther. 2022;7:135. doi: 10.1038/s41392-022-00974-4. - DOI - PMC - PubMed